insulin Archives - Dr Shawn

DoctorShawn

30/May/2023

Berberine and Ozempic are two medicines that have gained popularity in recently. Berberine is a natural supplement, while Ozempic is a prescription drug. Both have been shown to lower blood sugar and improve insulin sensitivity, making them popular among people with diabetes and weight loss. In this blog post, we will explore the similarities and differences between these two medicines.

1. What is Berberine?

Berberine is a remarkable natural compound, has been used for centuries in traditional Chinese and Ayurvedic medicine to treat a variety of ailments. Extracted from the roots, rhizomes, and stem bark of plants like goldenseal, Oregon grape, and barberry, berberine’s vibrant yellow color and impressive therapeutic properties have made it a prized ingredient in ancient healing practices.

The mechanism of action for berberine is quite fascinating. It functions by activating an enzyme called AMP-activated protein kinase (AMPK), which plays a critical role in regulating metabolism and maintaining cellular energy homeostasis. This activation leads to numerous health benefits, including improved insulin sensitivity, reduced inflammation, and enhanced lipid metabolism.

Recent scientific studies have confirmed berberine’s effectiveness in managing several conditions. One of its most notable applications is in treating type 2 diabetes, where it has exhibited remarkable potential in lowering blood sugar levels, comparable to the widely prescribed drug metformin. Additionally, berberine has demonstrated promising results in improving cardiovascular health by reducing cholesterol and triglyceride levels. It has also displayed antimicrobial properties against various bacteria, fungi, and parasites, making it a valuable ally in combating infections.

2. What is Ozempic?

Ozempic, also known as semaglutide, is a groundbreaking medication that has taken the world of diabetes management by storm. Developed by Novo Nordisk, Ozempic was approved by the US Food and Drug Administration (FDA) in 2017 for the treatment of type 2 diabetes in adults (FDA, 2017). This innovative drug belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists, which are designed to mimic the action of GLP-1, a naturally occurring hormone involved in regulating blood sugar levels.

The mechanism of action for Ozempic is truly fascinating. As a GLP-1 receptor agonist, it works by stimulating insulin secretion from pancreatic beta cells when blood sugar levels are high, thus helping to lower glucose levels in the bloodstream. Moreover, it suppresses the release of glucagon, a hormone that raises blood sugar levels, and slows down gastric emptying, resulting in a decrease in appetite and caloric intake.

Clinical trials have demonstrated Ozempic’s effectiveness in managing type 2 diabetes, showing significant reductions in HbA1c levels (a measure of long-term blood sugar control) and body weight. Additionally, it has been proven to reduce the risk of major cardiovascular events, such as heart attack and stroke, in patients with type 2 diabetes and established cardiovascular disease. With its promising results and innovative mechanism of action, Ozempic has emerged as a powerful tool in the ongoing battle against diabetes and its complications.

3. How does Berberine compare to Ozempic?

In terms of blood sugar regulation, berberine has been shown to lower blood glucose levels by activating AMP-activated protein kinase (AMPK), which helps improve insulin sensitivity and decrease insulin resistance. On the other hand, Ozempic mimics the action of GLP-1, stimulating insulin secretion from pancreatic beta cells when blood sugar levels are high, suppressing glucagon release, and slowing gastric emptying . Both compounds have demonstrated significant reductions in HbA1c levels, a measure of long-term blood sugar control, in patients with type 2 diabetes).

When it comes to weight loss, both berberine and Ozempic have shown promising results. Berberine’s activation of AMPK leads to enhanced lipid metabolism, contributing to weight loss (Turner et al., 2008). Ozempic’s effect on weight loss can be attributed to its ability to slow gastric emptying, resulting in reduced appetite and caloric intake. Clinical trials have demonstrated significant weight loss in patients with type 2 diabetes treated with either compound.

While both berberine and Ozempic have proven effective in managing blood sugar levels and promoting weight loss, their mechanisms of action differ, and they belong to different classes of compounds. Berberine is a natural compound with a broader range of applications, including antimicrobial and anti-inflammatory properties. Ozempic, as a synthetic GLP-1 receptor agonist, has been specifically developed for type 2 diabetes treatment and has demonstrated additional cardiovascular benefits in patients with established cardiovascular disease.

4. Can Berberine and Ozempic be taken together?

It is not advisable to take Berberine and Ozempic together without consulting a doctor. Both medicines can lower blood sugar levels, and taking them together can lead to hypoglycemia (low blood sugar). If you are already taking Ozempic, it is crucial to monitor your blood sugar levels regularly and follow your doctor’s advice on adjusting your medication.

5. Which one should you choose?

Generally, Berberine is a safer and more affordable option compared to Ozempic, especially for people with mild to moderate blood sugar problems. However, for people with severe diabetes or other health complications, Ozempic may be the better choice, as it is a more potent and targeted medication. Ultimately, the decision to use Berberine or Ozempic should be made in consultation with a physician or naturopathic doctor, who can assess your particular health needs and goals.

References:

Imanshahidi, M., & Hosseinzadeh, H. (2016). Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytotherapy Research, 22(8), 999-1012.

Turner, N., Li, J. Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., … & Xu, A. (2008). Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes, 57(5), 1414-1418.

Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712-717.

Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., … & Gong, H. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism, 93(7), 2559-2565.

Imanshahidi, M., & Hosseinzadeh, H. (2010). Berberis Vulgaris and Berberine: An Update Review. Phytotherapy Research, 22(11), 1485-1494.

FDA. (2017). FDA approves new drug to treat type 2 diabetes. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treat-type-2-diabetes

Aroda, V. R., Bain, S. C., Cariou, B., Piletic, M., Rose, L., Axelsen, M., … & Marre, M. (2017). Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial. The Lancet Diabetes & Endocrinology, 5(5), 341-354.

Nauck, M. A., Petrie, J. R., Sesti, G., Mannucci, E., Courrèges, J. P., Lindegaard, M. L., … & Madsbad, S. (2016). A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes. Diabetes Care, 39(2), 231-241.

Pratley, R. E., Amod, A., Hoff, S. T., Kadowaki, T., Lingvay, I., Nauck, M., … & Soska, V. (2018). Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial. The Lancet, 394(10192), 39-50.

Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., … & Seufert, J. (2016). Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. New England Journal of Medicine, 375(19), 1834-1844.

Sorli, C., Harashima, S. I., Tsoukas, G. M., Unger, J., Karsbøl, J. D., Hansen, T., & Bain, S. C. (2017). Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial. The Lancet Diabetes & Endocrinology, 5(4), 251-260.

drshawn

19/Oct/2022

You may have seen posts on social media about the benefits of fasting and how it can help improve immunity, but what does the science say? Is there any truth to these claims? Let’s take a closer look.

There are many different types of fasting diets, but the most common are intermittent fasting, alternate-day fasting, prolonged fasting and fast-mimicking. Some people fast for religious reasons, while others do it for health reasons. Let’s now examine some of the different types of fasting protocols.

Intermittent Fasting

Intermittent fasting is a type of fasting diet where you alternate between periods of eating and not eating, usually for a set number of hours each day.

One popular version of this diet is known as the 16:8 fasting to eating ratio, which involves fasting for 16 hours every day and then consuming all of your food during the remaining 8-hour window. This type of fasting has been shown to have several health benefits, including improved insulin sensitivity, fat loss, and increased longevity.

Alternate Day Fasting

Alternate day fasting is a type of fasting diet in which you alternate between periods of eating and not eating. During the fasting period, you typically consume a very low number of calories, usually less than 500 per day. Some people may choose to fast for 24 hours at a time, while others might fast for two days in a row before returning to normal eating patterns.

There are several potential benefits to this type of diet, including weight loss, improved blood sugar control, and increased longevity. However, there are also some potential risks associated with alternate day fasting, such as nutritional deficiencies and difficulty adhering to the diet over the long term.

Prolonged Fasting

Prolonged fasting is an alternative type of fasting diet that is designed to allow the body to enter into a state of ketosis, a metabolic state in which fat becomes the primary energy source instead of carbohydrates.

Unlike other forms of fasting where the specific timeframe for fasting may vary, prolonged fasting typically involves fasting for 3-5 days at a time with periods of normal eating in between. During this time, people may experience side effects like fatigue, lightheadedness, and hunger pangs.

However, proponents of prolonged fasting claim that this type of fast can help promote weight loss by effectively killing off certain cells in the body that are responsible for storing excess fat. Additionally, some research suggests that prolonged fasting may have other health benefits like improved insulin sensitivity and reduction in inflammation.

Fast Mimicking

The fast mimicking diet is a type of fasting diet that involves consuming specific foods and nutrients in order to mimic the effects of fasting. This approach is typically done over the course of 5 days, during which time people consume a low-calorie diet that is high in nutrients such as vitamins, minerals, and healthy fats. The goal of this type of fast is to trigger certain biological changes that are typically seen during periods of fasting, such as increased insulin sensitivity, reduced inflammation, and enhanced cellular repair.

While there haven’t been many large-scale studies examining the health benefits of fast mimicking diets, early research suggests that they may have a variety of positive effects on health and longevity.

Fasting and Immunity

There is some evidence to suggest that fasting can help boost immunity. One study found that intermittent fasting increased the production of white blood cells, which are your body’s first line of defense against infection. Another study found that alternate-day fasting improved markers of inflammation, which is thought to be involved in the development of some chronic diseases. Fasting also promotes a disease modifying process called autophagy.

Autophagy

Autophagy is a cellular process where the body breaks down damaged or unnecessary parts of cells in order to clear out harmful waste products and repair any damage. This process can be triggered by fasting, which has been shown to increase levels of autophagy throughout the body, helping to protect against disease and promote good health.

Studies have found that intermittent fasting can increase levels of certain proteins involved in the regulation of autophagy, while alternate-day fasting has been shown to induce autophagy even more effectively.

Additionally, researchers believe that fasting may help stimulate the production of stem cells, which are able to replace old or damaged cell tissues and potentially contribute to improved healing and recovery.

Overall, there is strong evidence that fasting can trigger autophagy in various ways, which may help boost immunity and prevent the development of chronic diseases.

Fasting Risks

It’s important to note that fasting is not for everyone. If you have a medical condition or are taking medication, please consult with your healthcare provider before starting any type of fasting diet. Fasting can also be dangerous if not done correctly. For example, if you don’t eat enough calories or nutrients, you may experience fatigue, irritability, and difficulty concentrating. You may also be at risk for dehydration if you are not drinking enough fluids.

Conclusion

So, should you start fasting to improve your immunity? Personally, fasting is the first thing I do when I feel a cold or flu coming on. I have found that this practice dramatically reduces symptoms and duration of illness. As you can see there is some research to support fasting as a natural immune system booster. It is important to note that fasting is not for everyone and can be dangerous if not done correctly. If you’re thinking about starting a fasting diet, please consult with your healthcare provider first.

Berberine, the Natural Ozempic? Exploring Similarities and differences