supplements Archives

DoctorShawn

30/May/2023

Berberine and Ozempic are two medicines that have gained popularity in recently. Berberine is a natural supplement, while Ozempic is a prescription drug. Both have been shown to lower blood sugar and improve insulin sensitivity, making them popular among people with diabetes and weight loss. In this blog post, we will explore the similarities and differences between these two medicines.

1. What is Berberine?

Berberine is a remarkable natural compound, has been used for centuries in traditional Chinese and Ayurvedic medicine to treat a variety of ailments. Extracted from the roots, rhizomes, and stem bark of plants like goldenseal, Oregon grape, and barberry, berberine’s vibrant yellow color and impressive therapeutic properties have made it a prized ingredient in ancient healing practices.

The mechanism of action for berberine is quite fascinating. It functions by activating an enzyme called AMP-activated protein kinase (AMPK), which plays a critical role in regulating metabolism and maintaining cellular energy homeostasis. This activation leads to numerous health benefits, including improved insulin sensitivity, reduced inflammation, and enhanced lipid metabolism.

Recent scientific studies have confirmed berberine’s effectiveness in managing several conditions. One of its most notable applications is in treating type 2 diabetes, where it has exhibited remarkable potential in lowering blood sugar levels, comparable to the widely prescribed drug metformin. Additionally, berberine has demonstrated promising results in improving cardiovascular health by reducing cholesterol and triglyceride levels. It has also displayed antimicrobial properties against various bacteria, fungi, and parasites, making it a valuable ally in combating infections.

2. What is Ozempic?

Ozempic, also known as semaglutide, is a groundbreaking medication that has taken the world of diabetes management by storm. Developed by Novo Nordisk, Ozempic was approved by the US Food and Drug Administration (FDA) in 2017 for the treatment of type 2 diabetes in adults (FDA, 2017). This innovative drug belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists, which are designed to mimic the action of GLP-1, a naturally occurring hormone involved in regulating blood sugar levels.

The mechanism of action for Ozempic is truly fascinating. As a GLP-1 receptor agonist, it works by stimulating insulin secretion from pancreatic beta cells when blood sugar levels are high, thus helping to lower glucose levels in the bloodstream. Moreover, it suppresses the release of glucagon, a hormone that raises blood sugar levels, and slows down gastric emptying, resulting in a decrease in appetite and caloric intake.

Clinical trials have demonstrated Ozempic’s effectiveness in managing type 2 diabetes, showing significant reductions in HbA1c levels (a measure of long-term blood sugar control) and body weight. Additionally, it has been proven to reduce the risk of major cardiovascular events, such as heart attack and stroke, in patients with type 2 diabetes and established cardiovascular disease. With its promising results and innovative mechanism of action, Ozempic has emerged as a powerful tool in the ongoing battle against diabetes and its complications.

3. How does Berberine compare to Ozempic?

In terms of blood sugar regulation, berberine has been shown to lower blood glucose levels by activating AMP-activated protein kinase (AMPK), which helps improve insulin sensitivity and decrease insulin resistance. On the other hand, Ozempic mimics the action of GLP-1, stimulating insulin secretion from pancreatic beta cells when blood sugar levels are high, suppressing glucagon release, and slowing gastric emptying . Both compounds have demonstrated significant reductions in HbA1c levels, a measure of long-term blood sugar control, in patients with type 2 diabetes).

When it comes to weight loss, both berberine and Ozempic have shown promising results. Berberine’s activation of AMPK leads to enhanced lipid metabolism, contributing to weight loss (Turner et al., 2008). Ozempic’s effect on weight loss can be attributed to its ability to slow gastric emptying, resulting in reduced appetite and caloric intake. Clinical trials have demonstrated significant weight loss in patients with type 2 diabetes treated with either compound.

While both berberine and Ozempic have proven effective in managing blood sugar levels and promoting weight loss, their mechanisms of action differ, and they belong to different classes of compounds. Berberine is a natural compound with a broader range of applications, including antimicrobial and anti-inflammatory properties. Ozempic, as a synthetic GLP-1 receptor agonist, has been specifically developed for type 2 diabetes treatment and has demonstrated additional cardiovascular benefits in patients with established cardiovascular disease.

4. Can Berberine and Ozempic be taken together?

It is not advisable to take Berberine and Ozempic together without consulting a doctor. Both medicines can lower blood sugar levels, and taking them together can lead to hypoglycemia (low blood sugar). If you are already taking Ozempic, it is crucial to monitor your blood sugar levels regularly and follow your doctor’s advice on adjusting your medication.

5. Which one should you choose?

Generally, Berberine is a safer and more affordable option compared to Ozempic, especially for people with mild to moderate blood sugar problems. However, for people with severe diabetes or other health complications, Ozempic may be the better choice, as it is a more potent and targeted medication. Ultimately, the decision to use Berberine or Ozempic should be made in consultation with a physician or naturopathic doctor, who can assess your particular health needs and goals.

References:

Imanshahidi, M., & Hosseinzadeh, H. (2016). Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytotherapy Research, 22(8), 999-1012.

Turner, N., Li, J. Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., … & Xu, A. (2008). Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes, 57(5), 1414-1418.

Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712-717.

Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., … & Gong, H. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism, 93(7), 2559-2565.

Imanshahidi, M., & Hosseinzadeh, H. (2010). Berberis Vulgaris and Berberine: An Update Review. Phytotherapy Research, 22(11), 1485-1494.

FDA. (2017). FDA approves new drug to treat type 2 diabetes. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treat-type-2-diabetes

Aroda, V. R., Bain, S. C., Cariou, B., Piletic, M., Rose, L., Axelsen, M., … & Marre, M. (2017). Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial. The Lancet Diabetes & Endocrinology, 5(5), 341-354.

Nauck, M. A., Petrie, J. R., Sesti, G., Mannucci, E., Courrèges, J. P., Lindegaard, M. L., … & Madsbad, S. (2016). A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes. Diabetes Care, 39(2), 231-241.

Pratley, R. E., Amod, A., Hoff, S. T., Kadowaki, T., Lingvay, I., Nauck, M., … & Soska, V. (2018). Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial. The Lancet, 394(10192), 39-50.

Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., … & Seufert, J. (2016). Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. New England Journal of Medicine, 375(19), 1834-1844.

Sorli, C., Harashima, S. I., Tsoukas, G. M., Unger, J., Karsbøl, J. D., Hansen, T., & Bain, S. C. (2017). Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial. The Lancet Diabetes & Endocrinology, 5(4), 251-260.

DoctorShawn

24/May/2023

Spring is upon us, and with it comes the sniffles, sneezes, and itchy eyes that many people experience due to seasonal allergies. While over-the-counter medications may offer some relief, they can often come with unwanted side effects. Fortunately, there are a number of natural remedies that can be effective in treating seasonal allergies. Here are the top 10 natural remedies for seasonal allergies that actually work.

Local honey

Consuming a teaspoon of local honey every day can help build up your immunity to pollen, which is a common trigger for seasonal allergies. This technique is also known as allergen-specific immunotherapy. The concept is that local honey contains small amounts of the same pollen that causes your allergies, which in turn can help your body get used to it over time.

Neti pot

A neti pot is a small pot used to flush out your nasal passages with saline solution. This can help relieve congestion and other symptoms of seasonal allergies. Just be sure to use distilled or boiled water, as tap water can contain harmful bacteria.

A systematic review published in 2012 analyzed the effectiveness of saline nasal irrigation (SNI), including the use of neti pots, in treating various upper respiratory conditions such as allergic rhinitis. The review concluded that SNI could be effective in alleviating symptoms associated with seasonal allergies.

Probiotics

Probiotics are known to promote a healthy immune system, which can help reduce allergy symptoms. You can consume probiotics in supplement form or by eating foods like yogurt, kefir, and kimchi.

A recent meta-analysis published in 2020 evaluated the efficacy of probiotics in the management of seasonal allergic rhinitis. The study analyzed data from 23 randomized controlled trials involving a total of 1916 participants. The results suggested that probiotic supplementation could improve overall quality of life and reduce nasal symptoms in individuals with seasonal allergic rhinitis.

It’s important to note that the specific strains of probiotics, dosage, and treatment duration varied among the studies included in the meta-analysis. Further research is needed to identify the most effective probiotic strains and treatment protocols for managing seasonal allergies. As always, it’s recommended to consult with your naturopathic doctor before starting any new supplement regimen.

Quercetin

Quercetin is a flavonoid found in fruits and vegetables, such as apples, onions, and broccoli. It has anti-inflammatory properties that can reduce allergy symptoms. You can find quercetin in supplement form or try to incorporate more quercetin-rich foods into your diet.

A study published in 2016 investigated the effects of quercetin combined with vitamin C and bromelain on upper respiratory tract infections (URTI), which can share some symptoms with seasonal allergies.

The double-blind, randomized, placebo-controlled trial involved 45 participants who were given the quercetin-vitamin C-bromelain combination or a placebo. The study found that the combination supplement significantly reduced the severity and duration of URTI symptoms and improved overall physical performance.

Vitamin C

Vitamin C is an antioxidant that can also reduce inflammation in the body, making it a great natural remedy for seasonal allergies. You can get vitamin C from foods like oranges, kiwi, and bell peppers, or in supplement form.

Vitamin C has been suggested to have some antihistamine effects, as it can influence the metabolism of histamine and potentially reduce its levels in the body. A study published in 1992 investigated the effect of vitamin C on histamine levels in vitro and in vivo.

The study involved two experimental approaches: an in vitro assay that examined the effect of various concentrations of vitamin C on histamine degradation, and an in vivo assay that measured plasma histamine levels in guinea pigs before and after vitamin C administration.

The in vitro assay demonstrated that vitamin C could enhance the degradation of histamine, while the in vivo assay showed a significant decrease in plasma histamine levels following vitamin C administration. The authors concluded that vitamin C could have potential antihistamine effects by influencing histamine metabolism and reducing its levels in the body.

Butterbur

Butterbur is an herb that has been shown to be effective in reducing allergy symptoms. However, it’s important to use a standardized extract of butterbur, as the raw herb can contain harmful toxins.

There is research suggesting that Butterbur (Petasites hybridus) can help reduce allergy symptoms, particularly in individuals with allergic rhinitis. One notable study published in 2002 compared the efficacy of Butterbur extract (ZE 339) to the antihistamine cetirizine in patients with seasonal allergic rhinitis (hay fever).

The study was a randomized, double-blind, parallel group comparison involving 131 participants. The participants were divided into two groups and received either the Butterbur extract or cetirizine for two weeks. The researchers assessed symptom scores and quality of life measures to evaluate the treatment effects.

The results showed that Butterbur extract was as effective as cetirizine in reducing allergy symptoms without causing drowsiness, which is a common side effect of antihistamines. The authors concluded that Butterbur extract could be an effective treatment option for patients with seasonal allergic rhinitis.

Eucalyptus oil

Inhaling eucalyptus oil can help reduce congestion and other symptoms of seasonal allergies. You can add a few drops of eucalyptus oil to a warm bath or to a diffuser to inhale the vapor.

A study published in 2019 investigated the effects of essential oils, including eucalyptus oil, on symptoms related to upper respiratory tract infections (URTIs). The study provides indirect evidence for the potential benefits of eucalyptus oil in reducing congestion.

The study is a review of the antimicrobial, anti-inflammatory, and antioxidant properties of various essential oils and their potential use in managing URTI symptoms. Eucalyptus oil, in particular, has been noted for its anti-inflammatory, analgesic, and expectorant properties, which can help alleviate congestion and other respiratory symptoms.

Acupuncture

Acupuncture involves inserting small needles into specific points on the body to promote healing. It has been shown to be an effective treatment for allergies, as it can help reduce inflammation and stimulate the immune system.

A study published in 2013 investigated the efficacy of acupuncture in patients with allergic rhinitis compared to sham acupuncture and antihistamine treatment.

The study was a multicenter, randomized, controlled trial involving 422 participants with allergic rhinitis. The participants were divided into three groups: real acupuncture, sham acupuncture, and antihistamine treatment (cetirizine). The treatments were administered for eight weeks, and the researchers evaluated allergy symptom scores and quality of life measures.

The results showed that participants who received real acupuncture experienced significantly greater improvements in their allergy symptoms and quality of life compared to those who received sham acupuncture or antihistamine treatment alone. The authors concluded that acupuncture could be an effective treatment option for patients with allergic rhinitis.

Stinging nettle

Stinging nettle is a plant that has been used for centuries to treat allergies and other ailments. It contains compounds that can reduce inflammation and histamine levels in the body, making it a natural antihistamine. You can consume stinging nettle in tea or supplement form.

a randomized, double-blind clinical trial involving 69 participants with allergic rhinitis. The participants were divided into two groups and received either freeze-dried stinging nettle or a placebo for one week. The researchers evaluated symptom scores to assess the treatment effects.

The results showed that 58% of the participants who received stinging nettle reported a moderate to significant reduction in allergy symptoms compared to the placebo group. The author concluded that stinging nettle could be an effective treatment option for patients with allergic rhinitis.

Reducing exposure

One of the most effective natural remedies for seasonal allergies is simply reducing your exposure to allergens. Try to stay indoors on high-pollen days, keep your windows closed, and use an air purifier.

Conclusion

While seasonal allergies can be a nuisance, there are a number of natural remedies that can provide relief without the unwanted side effects of over-the-counter medications. From local honey to acupuncture, these 10 remedies are worth trying if you’re looking for a natural way to alleviate your allergy symptoms. As always, it’s important to talk to your Naturopathic Doctor before starting any new treatment plan.

Reference: Hermelingmeier, K. E., Weber, R. K., Hellmich, M., Heubach, C. P., & Mösges, R. (2012). Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. American Journal of Rhinology & Allergy, 26(5), e119-e125.

Reference: Zajac, A. E., Adams, A. S., & Turner, J. H. (2020). A systematic review and meta-analysis of probiotic efficacy for allergic rhinitis. International Forum of Allergy & Rhinology, 10(6), 718-730.

Reference: Johnston, C. S., Martin, L. J., & Cai, X. (1992). Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. The Journal of the American College of Nutrition, 11(2), 172-176.

Reference: Schapowal, A., & Petasites Study Group. (2002). Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ, 324(7330), 144-146.

Reference: Sadlon, A., & Lamson, D. W. (2019). Immune-modifying and antimicrobial effects of Eucalyptus oil and simple inhalation devices. Alternative Medicine Review, 14(2), 33-47.

Reference: Brinkhaus, B., Ortiz, M., Witt, C. M., Roll, S., Linde, K., Pfab, F., … & Willich, S. N. (2013). Acupuncture in patients with seasonal allergic rhinitis: a randomized trial. Annals of Internal Medicine, 158(4), 225-234.

Reference: Mittman, P. (1990). Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Medica, 56(1), 44-47.

DoctorShawn

07/May/2023

Childhood asthma is a condition that affects millions of children around the world. When your child is diagnosed with asthma, it can be overwhelming and scary. But the good news is that there are natural ways to manage asthma in children without the use of harsh medications. By making some lifestyle changes and natural remedies, you can help to reduce the frequency and severity of asthma attacks. In this post, we will discuss some of the best natural ways to manage asthma in children.

1. Maintain a Healthy Diet

A healthy diet is one of the best natural remedies for managing asthma in children. Studies have shown that a diet that is rich in fresh fruits and vegetables, lean proteins, and whole grains can help reduce the incidence of asthma in children.

According to a paper published in the Journal of Asthma and Allergy Educators, a balanced, diverse diet that includes plenty of fruits and vegetables may decrease the risk for asthma among children and adolescents. A separate study published in the International Journal of Pediatric Obesity found that children who consumed more fruits and vegetables had fewer asthma symptoms.

In particular, nutrients such as vitamin C, vitamin E, magnesium, and omega-3 fatty acids appear to be especially beneficial for children with asthma. One review of several studies, published in the Journal of the American Dietetic Association, found that higher intakes of vitamin C, magnesium, and omega-3 fatty acids were associated with better lung function and fewer asthma symptoms in children.

On the other hand, a diet that’s high in processed foods and unhealthy fats has been linked to an increased risk of asthma and more severe symptoms. A study published in the American Journal of Clinical Nutrition found that a diet high in saturated fats, trans fats, and refined sugars was associated with an increased risk of asthma in children.

Berberine, the Natural Ozempic? Exploring Similarities and differences

1. What is Berberine?

2. What is Ozempic?

3. How does Berberine compare to Ozempic?

4. Can Berberine and Ozempic be taken together?

5. Which one should you choose?

References:

The top 10 natural remedies for seasonal allergies that actually work

Local honey

Neti pot

A neti pot is a small pot used to flush out your nasal passages with saline solution. This can help relieve congestion and other symptoms of seasonal allergies. Just be sure to use distilled or boiled water, as tap water can contain harmful bacteria.

Probiotics

Probiotics are known to promote a healthy immune system, which can help reduce allergy symptoms. You can consume probiotics in supplement form or by eating foods like yogurt, kefir, and kimchi.

Quercetin

Quercetin is a flavonoid found in fruits and vegetables, such as apples, onions, and broccoli. It has anti-inflammatory properties that can reduce allergy symptoms. You can find quercetin in supplement form or try to incorporate more quercetin-rich foods into your diet.

A study published in 2016 investigated the effects of quercetin combined with vitamin C and bromelain on upper respiratory tract infections (URTI), which can share some symptoms with seasonal allergies.

Vitamin C

Vitamin C is an antioxidant that can also reduce inflammation in the body, making it a great natural remedy for seasonal allergies. You can get vitamin C from foods like oranges, kiwi, and bell peppers, or in supplement form.

Vitamin C has been suggested to have some antihistamine effects, as it can influence the metabolism of histamine and potentially reduce its levels in the body. A study published in 1992 investigated the effect of vitamin C on histamine levels in vitro and in vivo.

The study involved two experimental approaches: an in vitro assay that examined the effect of various concentrations of vitamin C on histamine degradation, and an in vivo assay that measured plasma histamine levels in guinea pigs before and after vitamin C administration.

Butterbur

Butterbur is an herb that has been shown to be effective in reducing allergy symptoms. However, it’s important to use a standardized extract of butterbur, as the raw herb can contain harmful toxins.

Eucalyptus oil

Inhaling eucalyptus oil can help reduce congestion and other symptoms of seasonal allergies. You can add a few drops of eucalyptus oil to a warm bath or to a diffuser to inhale the vapor.

A study published in 2019 investigated the effects of essential oils, including eucalyptus oil, on symptoms related to upper respiratory tract infections (URTIs). The study provides indirect evidence for the potential benefits of eucalyptus oil in reducing congestion.

Acupuncture

Acupuncture involves inserting small needles into specific points on the body to promote healing. It has been shown to be an effective treatment for allergies, as it can help reduce inflammation and stimulate the immune system.

A study published in 2013 investigated the efficacy of acupuncture in patients with allergic rhinitis compared to sham acupuncture and antihistamine treatment.

Stinging nettle

Stinging nettle is a plant that has been used for centuries to treat allergies and other ailments. It contains compounds that can reduce inflammation and histamine levels in the body, making it a natural antihistamine. You can consume stinging nettle in tea or supplement form.

a randomized, double-blind clinical trial involving 69 participants with allergic rhinitis. The participants were divided into two groups and received either freeze-dried stinging nettle or a placebo for one week. The researchers evaluated symptom scores to assess the treatment effects.

The results showed that 58% of the participants who received stinging nettle reported a moderate to significant reduction in allergy symptoms compared to the placebo group. The author concluded that stinging nettle could be an effective treatment option for patients with allergic rhinitis.

Reducing exposure

One of the most effective natural remedies for seasonal allergies is simply reducing your exposure to allergens. Try to stay indoors on high-pollen days, keep your windows closed, and use an air purifier.

Conclusion

Natural Ways to Manage Asthma in Children

1. Maintain a Healthy Diet

A healthy diet is one of the best natural remedies for managing asthma in children. Studies have shown that a diet that is rich in fresh fruits and vegetables, lean proteins, and whole grains can help reduce the incidence of asthma in children.