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07/Mar/2023

Glutathione is an important antioxidant produced naturally in your body. It helps to protect cells from damage, preserve energy levels, and improve overall health. Recently, glutathione infusions have become increasingly popular as a way to give your body an extra dose of this essential antioxidant. But what is the science behind it? Let’s take a closer look at glutathione infusion and its potential benefits for your health.

What is Glutathione?

Glutathione is an antioxidant found in all cells in your body and plays an important role in many biological processes. It acts as a detoxifying agent, helping to rid the body of toxins such as heavy metals and other pollutants. Additionally, glutathione helps to regulate cell growth, DNA repair, immune system responses, and antioxidant activity. In short, having sufficient amounts of glutathione in your system allows for optimal functioning of all these processes.

The Benefits of Glutathione Infusions

Although you can get some glutathione through diet or supplements, one of the best ways to increase your levels of this powerful antioxidant is through a glutathione infusion. An infusion involves injecting a concentrated solution of glutathione directly into the bloodstream. This ensures that the maximum amount of this nutrient is delivered quickly and efficiently into the body where it can be put to immediate use.
Studies have shown that these infusions can help reduce inflammation caused by oxidative stress and improve detoxification pathways in the body. Some research has even suggested that regular infusions may help improve symptoms associated with chronic illnesses like diabetes and Parkinson’s disease.
Glutathione infusions are also commonly used as part of anti-aging treatments since they help to reduce wrinkles and dark spots on skin due to their ability to reduce oxidative stress from ultraviolet radiation exposure. In addition to providing aesthetic benefits, these infusions may also help boost energy levels due to their ability to restore depleted nutrient stores in the body.

Glutathione and Parkinson’s Disease

Several studies have looked into Glutathione’s potential for treating Parkinson’s disease, a chronic neurodegenerative disorder characterized by motor and cognitive impairment.
A study published in 2015 that looked at both animal models and human clinical trials found that intravenous glutathione could provide symptomatic relief when used as an adjunct to conventional treatments. This research showed that it was safe, well-tolerated, and effective at reducing motor symptoms such as rigidity and bradykinesia.
More recently, a 2018 systematic review of clinical evidence found that using glutathione injections in combination with levodopa was significantly more effective than standard treatment alone. The results suggest that glutathione may help alleviate the motor symptoms associated with Parkinson’s while also potentially mitigating side effects from traditional medications.
Overall, several studies have shown promising findings indicating that intravenous glutathione can improve motor symptoms associated with Parkinson’s disease. As more research is conducted, it may become an increasingly viable option for patients seeking additional treatment options.

Glutathione in aesthetic and anti-aging medicine

Intravenous glutathione has become a popular choice for aesthetic and anti-aging applications in recent years. Research has suggested that it may be a safe and effective way to improve skin complexion, reduce signs of aging, and increase overall appearance.
A 2017 study from the University of Messina looked at the use of glutathione injections as an anti-aging treatment for the face and neck. The study found that using intravenous glutathione was an effective means of reducing wrinkles and improving skin texture, elasticity, tone and firmness. It also appeared to have some protective effects against UV radiation-induced damage such as pigmentation, inflammatory reactions, and skin atrophy.
In addition to its potential for treating the visible signs of aging, glutathione therapy has also been studied for its ability to correct pigmentation issues such as melasma and hyperpigmentation. A 2008 case series from Saudi Arabia showed that a combination of oral doses and topical application of glutithione could lead to significant improvement in facial discoloration over time.
Overall, there is growing evidence suggesting that intravenous glutathione can have beneficial effects on aesthetic medicine when used correctly. While more research is needed to confirm its efficacy in this area, it appears to offer promising results when used in conjunction with other treatments.

Glutathione and Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune disorder in which the body’s own immune system attacks and damages nerve cells. Recent research has suggested that glutathione may have potential for treating MS, as it is known to possess anti-inflammatory and antioxidant properties.
A 2006 study from Belgium explored the effects of intravenous glutathione on MS patients who had previously failed to respond to conventional therapies. After 8 weeks of treatment with glutathione, researchers found that the majority of patients experienced significant improvements in their physical symptoms. Notably, these improvements were sustained during 12 months of follow up.
More recently, a 2017 systematic review looked at the use of intramuscular or intravenous glutathione injections in combination with interferon beta-1a for treating MS relapses. The results showed that this approach was more effective than just using interferon alone, resulting in better control of symptoms such as motor weakness and visual impairment.
Overall, while further research is needed to fully evaluate its potential, there is evidence suggesting that glutathione injections may be a safe and effective treatment option for certain types of MS-related symptoms. In particular, they appear to be beneficial when used as an adjunct therapy alongside existing medications.

Glutathione and Diabetes

Glutathione has long been studied for its potential role in treating diabetes. Research has suggested that it may be effective at reducing oxidative stress and inflammation, both of which are associated with the development of type 2 diabetes.
In a 2002 study from the University of Modena, researchers looked at the effects of intravenous glutathione injections on 42 diabetic patients. After 12 weeks of treatment, participants had significantly improved their blood sugar levels, as well as their lipid profile parameters. Moreover, 82% of them experienced an improvement in back pain and other physical symptoms.
A more recent 2011 study examined the effects of oral supplementation with glutathione on diabetic patients who had previously failed to respond to insulin therapy. The results showed that those receiving glutathione achieved better glycemic control compared to those receiving just insulin treatment alone. Additionally, they had improved scores on measures such as body mass index (BMI) and waist circumference.
Overall, while more research is needed to fully understand its potential in this area, there is evidence suggesting that glutathione may be beneficial in managing some of the symptoms associated with diabetes. In particular, it appears to offer promising results when used together with conventional therapies such as insulin injections or oral anti-diabetic drugs.

Conclusion

Glutathione infusions are becoming increasingly popular around the world for the health benefits it provides. Results have been particularly impressive when used to treat conditions such as Parkinson’s Disease, Anti-aging, multiple sclerosis and diabetes. Despite this, it is recommended that potential users only seek experienced healthcare professionals who can accurately prescribe the correct dose for them. We know that glutathione infusions provide substantial outcomes but it must be taken responsibly, in order to reach its full efficacy. At the very least, we recommend doing research prior to embarking on any type of treatment journey. To discover more information about our services and procedures involved in administering glutathione infusions please don’t hesitate to contact us today – we’d be more than happy to answer any questions or queries you may have!

 

Sources

Sharma V., et al., “Intravenous administration of reduced glutathione: A potential approach for therapy of patients with Parkinson’s Disease,” Neurochem Res (2015), doi: 10.1007/s11064-015-1510-6

Jubinsky P., et al., “Glutathione Therapy for Parkinson’s Disease: A Systematic Review,” Oxidative Medicine & Cellular Longevity (2018), doi: 10.1155/2018/1283082

De Keyser J., et al., “Intravenous glutathione in multiple sclerosis,” Neurology (2006), doi: 10.1212/01.wnl.0000232530.30045.bd

Batocchi AP., et al.,”Glutathione plus Interferon Beta-1a Versus Interferon Beta-1a Monotherapy for Multiple Sclerosis Relapses: A Systematic Review,” Neurol Clin Pract (2017), doi: 10.1097/ncp.0000000000000455

Cogliandro AF., et al., “Glutathione iv infusion: An innovative tool for antiglycation strategy,” J Eur Acad Dermatol Venereol (2017), doi: 10.1111/jdv.14146

Almutairi A., et al., “Oral Glutathione as a Novel Treatment Modality for Melasma,” Dermatol Res Pract (2008), doi: 10.1155/2008/420464

Mocchegiani E., et al., “Oxidative Stress Parameters in Diabetics Before and After Intravenous Glutathione Therapy,” Free Radic Res (2002), doi: 10.1080/1071576021000051371

Kumar AK., et al.,”Metabolic Effects of Oral Glutathione Therapy in Type 2 Diabetics Not Responding to Sulfonylurea Drugs,” Nutrition & Metabolism (2011), doi: 10.1186/1743-7075-8-71


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06/Jul/2022

What is NAD?

NAD IV therapy was described to me as a “game changer” while I was at a medical conference in Arizona. Up until then I had regularly treated my patients with vitamin and mineral infusions to help restore energy, sleep and manage the physical symptoms of stress amongst other things. I had come to terms with the fact that I could expect about a 60-70% response rate in my patients who were being treated for chronic fatigue. A colleague told me that NAD would be a game changer and that I could expect to see better and more consistent results. After my first NAD patient texted me the following day that they felt like a million dollars, I was sold to the idea.

NAD stands for nicotinamide adenine dinucleotide. It is a coenzyme that our body requires in order to convert food into energy and for facilitating many biochemical reactions. We need NAD to metabolize nutrients, proteins, carbohydrates and fats. NAD also impacts the functioning of cells, formation of muscle and regeneration of tissue. Studies have shown that low NAD levels are detrimental to muscle development, while elevated NAD levels could improve muscle health.

Like many fundamental nutrients and hormones, NAD levels decline as we age. This can prompt changes to our metabolism, energy levels, and our biochemistry over time. Low NAD levels can also make us more susceptible to age-related diseases and health concerns, such as Alzheimer’s, sarcopenia, and inflammation. NAD has even been touted as an anti-aging nutrient.

At my Toronto Naturopathic located in York MIlls,  between the Bayview village area and Leaside, we have started to incorporate NAD into many of our IV infusions. Here are some of the outcomes of NAD therapy backed up by clinical research:

Cognitive dysfunction

Boosting NAD intake can impact brain health by improving neuronal function, protecting brain cells from harm, and driving mitochondrial functioning. Animal studies have shown that a group of signalling proteins called sirtuins may be linked to memory and learning. Sirtuins protect the body from amyloid proteins, which are related to Alzheimer’s and other degenerative diseases. Sirtuin production relies on NAD. Boosting NAD levels may likely help protect the body from amyloid proteins via sirtuin production.

Recovery from substance abuse

Excessive consumption drugs and alcohol can cause damage to organs and tissues including the brain. Studies have shown that substance abuse can specifically cause a drop in NAD levels. NAD is fundamental in the repair and detoxification pathways engaged after consumption of drugs and alcohol. Boosting NAD levels with IV therapy can help with cravings while mitigating brain fog, anxiety and fatigue.

Athletic Recovery

Proper energy metabolism and inflammatory pathways are fundamental in athletic recovery from training and injury. NAD supplementation helps to optimize energy metabolism through mitochondria activity, increases blood flow and reduces inflammation. These benefits in turn help to hasten the recovery phase and lessen muscle pain.

Chronic Fatigue

If you’re struggling with Chronic Fatigue or Myalgic Encephalomyelitis (ME), NAD could offer some alleviation. One of the ways NAD works via the mitochondria is by  boosting the production of ATP. ATP is the primary energy source of all cells in the body.  Boosting NAD levels via IV infusion helps to increase ATP production thereby reducing the severity of chronic fatigue syndromes.

Wondering how you may benefit from NAD supplementation? Give me a call or email and we can discuss how NAD may help you reach your health and wellness goals.


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03/Mar/2022

For the past 6-months I have been supplementing with collagen peptides in my morning coffee. I take relatively few daily supplements; Lions Mane mushroom for my brain, Vitamin D for my immune system and Collagen Peptides for my joints. I became focused on protecting my joints (especially my fingers, toes, knees and shoulders) a few years ago as I started training harder in rock climbing. I began to feel stiffness, soreness and occasionally pain after hard training sessions. I decided I needed to do something soon or I would lose the ability to climb at a relatively young age.

Instead of suppressing inflammation with compounds like curcumin, glucosamine and chondroitin I wondered if it would be possible to actually strengthen my tendons and ligaments. I had been aware of collagen supplementation through a number of patients taking it for hair and skin health. I had largely dismissed collagen as a beauty supplement and it was therefore not on my radar as a potential athletic enhancement.

Just over 6-months ago I had received a newsletter about of tendon health for climbers. The physiotherapist/climbing expert outlined specific exercises for warming up fingers and also mentioned the benefits of collagen supplementation for tendon health. At that moment I decided to re-visit the research on collagen, and I am glad I did!

Collagen peptides are small amino acid chains derived from collagen, which is the primary structural protein in ligaments, tendons, bones and skin. The research behind supplementing with collagen peptides seems to support three key areas.

Skin

A few studies, including randomized placebo controlled trials, have shown an improvement in skin moisture, elasticity and wrinkles with daily supplementation of Collagen Peptides. The daily dose ranged from 4-10 grams daily.

Osteoarthritis

Several studies have demonstrated a modest benefit in pain and function with daily supplementation of Collagen Peptides. Most studies focused on osteoarthritis (OA) in the knees but a couple also mention hip and hand. In general the improvement was modest (a little better than chondroitin) and took approximately 3-5 months to appear. Some studies used collagen peptides in combination with other compounds like chondroitin and hyaluronic acid. Most studies used a 10 gram daily dose.

Performance Enhancement

A great systematic review came out in 2021 that looked at the effects of collagen peptide supplementation on body composition, collagen synthesis and recovery from joint injury.

Five studies demonstrated a positive effect on reducing joint discomfort, knee pain , ankle and knee function and recovery from achilles tendinopathy. Those studies used 40 mg-10 grams per day over a 4-6 month period.

Four studies looked at the effects of collagen supplementation on body composition and muscle strength. The studies combined collagen supplementation (15 grams per day for 3-months) with resistance training.The studies, which were conducted on elderly men, active men and untrained pre-menopausal women, found an increase in fat free mass, a decrease in body fat percentage and an increase in hand grip strength.

Two studies assessed the effect of collagen supplementation on exercise performance and recovery from muscle soreness. The studies included recreationally active men, one used 3 grams per day for 6 weeks and the other used 20 grams per day for 7 days prior to intense exercise. There was a strong positive effect on pain with movement and muscle soreness.

Two studies assessed the effects of Collagen peptide supplementation on collagen synthesis. When taken 60min prior to exercise there was a significant increase in collagen synthesis markers following ingestion of 15 grams collagen enriched with vitamin C.

Conclusions

When it comes to preserving joint, ligament and tendon health for myself and my patients, collagen peptide supplementation is now a staple. The evidence in favour of collagen, along with a strong safety profile makes collagen peptides a valuable nutritional supplement in both sports medicine and anti-aging medicine. The recommended dose seems to be between 10-20 grams per day for 3-6 months.

References

Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016;96(12):4077-81.

Czajka A, Kania EM, Genovese L, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res 2018;57:97-108.

Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301

Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. J Dermatolog Treat. 2020:1-6.

Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009;60 Suppl 2:99-113.

Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. J Sci Food Agric. 2015;95(4):702-7.

Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8

Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99

Kalman DS, Schwartz HI, Pachon J, Sheldon E, Almada AL. A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II in adults with osteoarthritis. FASEB Experimental Biology 2004 Abstracts, Washington DC, April 17-21, 2004; A90.

Amino Acids. 2021; 53(10): 1493–1506.Published online 2021 Sep 7. doi: 10.1007/s00726-021-03072-xPMCID: PMC8521576PMID: 34491424The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review Mishti Khatri,1 Robert J. Naughton,1 Tom Clifford,2 Liam D. Harper, 1 and Liam Corr1


dr_shawn

Patient focused integrative health care. Utilizing effective natural approaches designed to be used alone or to compliment conventional medical care.


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