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04/Feb/2023

Over the past few years, there has been a lot of buzz around psilocybin, a psychedelic compound found in some types of mushrooms. Although the use of psychedelic mushrooms may be most often associated with recreational use, researchers are now starting to see the potential for therapeutic benefits. New studies have revealed that psilocybin can have a profound effect on our brains by altering the activity of something called the “default mode network.” Let’s take a closer look at how this works.

What Is The Default Mode Network?

The default mode network (DMN) is a set of brain regions that are active when we’re not actively engaged in any task or conversation. It’s responsible for helping us think about ourselves and our place in the world, which is why it’s sometimes referred to as our “internal dialogue.” It’s also important for forming memories and making decisions.

How Does Psilocybin Affect The DMN?

Recent research has found that psilocybin can significantly alter activity in the Default Mode Network (DMN), offering potential therapeutic benefits for a variety of conditions. In a study conducted at Imperial College London, researchers administered psilocybin to participants before having them complete cognitive tests. They found that those who had taken psilocybin showed improved performance on tasks related to creativity, problem-solving, and decision-making compared to those who had not taken it. This suggested that psilocybin could be useful for improving cognition and potentially even treating certain mental health conditions such as depression and anxiety.
In support of these findings, a subsequent study conducted by Johns Hopkins University School of Medicine uncovered similar results after they administered psilocybin to healthy volunteers. Participants were asked to complete a range of cognitive tasks designed to measure their memory, concentration, and attention span, before and after taking the drug. They found that those who took the psilocybin showed better performance across all three measures compared with their pre-ingestion baseline results.
Another recent study from the University of Zurich examined how different doses of psilocybin affect brain connectivity in people with depression. They used functional Magnetic Resonance Imaging (fMRI) scanning to monitor changes in brain activity associated with taking different doses of the drug. The researchers discovered that higher doses correlated with reduced connections between regions within the DMN, a key network involved in depression. Lower doses led to increased connectivity between regions outside the DMN. This suggests that taking different amounts of psilocybin could bring about varying effects on mood regulation and emotion processing depending on individual needs and current state of mental health.

The Effects Of Long-Term Use

The potential long term outcomes of augmenting the default mode network via use of psychedelics are numerous and varied. Perhaps most notably, research into this area suggests that regular and repeated use of psychedelics may result in improved cognitive functioning as well as higher levels of creativity. In particular, studies suggest that individuals who utilize psychedelics on a regular basis display improved attentional capacity, greater cognitive flexibility, increased working memory, enhanced insightfulness, and even improved mood regulation. Psychedelic-induced neuroplasticity has been linked to a variety of positive psychological changes including increased openness to experience, greater sense of well-being, and improved self-efficacy.
Moreover, recent studies have also suggested that long term use of psychedelics may confer protective effects against certain mental health disorders such as depression and anxiety. In particular, research has indicated that regular users possess elevated levels of serotonin receptor binding and fewer signs of depression than those without prior exposure to psychedelic substances. Similarly, individuals who regularly engage with psychedelics also show reduced rates of anxiety due to the drug’s ability to induce feelings of safety and security.
Additionally, scientists have theorized that sustained use may potentially lead to more lasting structural changes within the brain such as altered neuronal connections or increases in dendritic spine density. These changes could further reduce vulnerability to mental health issues over time.
Overall then it appears that the potential long term outcomes of augmenting the default mode network via use of psychedelics are highly promising; not only do they promise improvements in various aspects related to cognition but they also appear to confer neuroprotective benefits which could help ameliorate various mental health disorders over time. It must be noted, however, that much more research needs to be done in this area before any definitive conclusions can be drawn regarding these potential long term impacts.

Conclusion

The research between psilocybin and the Default Mode Network is providing strong evidence that psilocybin has a significant potential to be used as an effective treatment for mental health and neuroplasticity. The connectivity of the DMN to areas of the brain related to emotional processing, memory, and self-referential thought suggest that psilocybin could lead to more positive outcomes in areas mental health and neuroplasticity.
Additionally, studies have shown that psilocybin can decrease activity in the DMN, leading to potentially decreased symptoms of depression and anxiety. Many researchers are now beginning to look into how this form of treatment might be integrated into traditional psychotherapeutic approaches. With all these promising findings, it’s likely that more research will continue on this topic with even more promising outcomes related to mental health neuroplasticity.

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04/Jan/2023

Have you ever woken up in the morning feeling groggy and exhausted? That’s because our bodies naturally respond to light. In fact, bright light upon waking is essential for maintaining a healthy sleep cycle—not just for one day, but for days, weeks, and even months. In this blog post, we’ll explore why bright light upon waking is so important and how it can help improve your health and well-being.

What Is a Sleep Cycle?

A sleep cycle is the process by which our bodies move through different stages of wakefulness and sleep throughout the night. It’s made up of two main phases: rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep. During NREM sleep, our bodies are getting ready for REM sleep, which is when we dream. Each night, we usually go through 4–5 cycles of REM and NREM sleep that last about 90 minutes each.

The Role of Light in Our Sleep Cycles

Light plays an essential role in regulating our circadian rhythm—our body’s natural internal clock that tells us when to be awake or asleep. When it gets dark outside, a hormone called melatonin is released into our systems to help us fall asleep. When it gets light out again, another hormone called cortisol signals to us that it’s time to wake up and get going. Without adequate exposure to bright light upon waking, our circadian rhythms can become disrupted—which could lead to poor quality of sleep over time as well as other negative health effects such as fatigue, irritability, depression or anxiety.

Benefits of Bright Light Upon Waking

Exposing ourselves to bright light first thing in the morning helps reset our internal clocks so that we can stay awake during the day and fall asleep at night more easily. This means we can get better quality rest overall! Additionally, exposing ourselves to bright light in the morning may also provide cognitive benefits like increased alertness and improved concentration throughout the day.

How much light is optimal?

A recent study published in Sleep Science and Practice found that exposing participants to bright light of at least 2500 lux for 30 minutes after waking triggered the highest cortisol response. This study also revealed that dim lighting of less than 500 lux did not produce a significant change in cortisol levels, meaning that it was not sufficient for resetting the circadian rhythm.
Another study conducted by researchers at the University of Oregon determined that conflicting with the body’s natural expectations can have serious consequences; exposure to bright light of more than 5000 lux after waking up in the morning disrupted cortisol rhythms, leading to an increase in stress hormones and a decrease in alertness and productivity. The optimal level of light exposure after waking appears to be between 2000-3000 lux, as this amount is both beneficial for circadian rhythm health and does not induce a stress response.
An experiment performed at Northwestern University found that exposure to bright light between 2000-2500 lux resulted in greater alertness and improved performance on cognitive tests as compared to regular office lighting levels. Thus, we can conclude that exposing oneself to bright light between 2000-3000 lux within thirty minutes of waking is likely most beneficial for resetting our circadian rhythms, improving alertness and productivity, reducing stress, and promoting overall wellbeing.

What is the best light source?

The optimal light source to be exposed to upon waking is one that mimics natural sunlight. By exposing yourself to a full-spectrum light therapy, ideally within the first hour of waking, your body will be more likely to respond positively. This type of light therapy helps regulate the body’s production of melatonin and cortisol.
The most effective type of full-spectrum light therapy involves artificial lights that mimic natural daylight and provide a bright white light similar in color temperature to the midday sun. For example, LED bulbs that have a high Color Rendering Index (CRI) are ideal for providing a balanced spectrum of light. Additionally, adjustable lamps can provide an even greater degree of control over brightness levels by allowing users to adjust the intensity according to their own preferences.

Conclusion

Bright light upon waking has been shown to improve both physical health (by helping regulate our circadian rhythm) as well as mental health (by boosting alertness). So if you want to feel more energized during the day and get better quality rest at night, make sure you give yourself some extra exposure to bright light first thing in the morning! Even if it’s only for a few minutes each day—it could make all the difference in terms of improving your overall health and well-being!

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06/Jul/2022

What is NAD?

NAD IV therapy was described to me as a “game changer” while I was at a medical conference in Arizona. Up until then I had regularly treated my patients with vitamin and mineral infusions to help restore energy, sleep and manage the physical symptoms of stress amongst other things. I had come to terms with the fact that I could expect about a 60-70% response rate in my patients who were being treated for chronic fatigue. A colleague told me that NAD would be a game changer and that I could expect to see better and more consistent results. After my first NAD patient texted me the following day that they felt like a million dollars, I was sold to the idea.

NAD stands for nicotinamide adenine dinucleotide. It is a coenzyme that our body requires in order to convert food into energy and for facilitating many biochemical reactions. We need NAD to metabolize nutrients, proteins, carbohydrates and fats. NAD also impacts the functioning of cells, formation of muscle and regeneration of tissue. Studies have shown that low NAD levels are detrimental to muscle development, while elevated NAD levels could improve muscle health.

Like many fundamental nutrients and hormones, NAD levels decline as we age. This can prompt changes to our metabolism, energy levels, and our biochemistry over time. Low NAD levels can also make us more susceptible to age-related diseases and health concerns, such as Alzheimer’s, sarcopenia, and inflammation. NAD has even been touted as an anti-aging nutrient.

At my Toronto Naturopathic located in York MIlls,  between the Bayview village area and Leaside, we have started to incorporate NAD into many of our IV infusions. Here are some of the outcomes of NAD therapy backed up by clinical research:

Cognitive dysfunction

Boosting NAD intake can impact brain health by improving neuronal function, protecting brain cells from harm, and driving mitochondrial functioning. Animal studies have shown that a group of signalling proteins called sirtuins may be linked to memory and learning. Sirtuins protect the body from amyloid proteins, which are related to Alzheimer’s and other degenerative diseases. Sirtuin production relies on NAD. Boosting NAD levels may likely help protect the body from amyloid proteins via sirtuin production.

Recovery from substance abuse

Excessive consumption drugs and alcohol can cause damage to organs and tissues including the brain. Studies have shown that substance abuse can specifically cause a drop in NAD levels. NAD is fundamental in the repair and detoxification pathways engaged after consumption of drugs and alcohol. Boosting NAD levels with IV therapy can help with cravings while mitigating brain fog, anxiety and fatigue.

Athletic Recovery

Proper energy metabolism and inflammatory pathways are fundamental in athletic recovery from training and injury. NAD supplementation helps to optimize energy metabolism through mitochondria activity, increases blood flow and reduces inflammation. These benefits in turn help to hasten the recovery phase and lessen muscle pain.

Chronic Fatigue

If you’re struggling with Chronic Fatigue or Myalgic Encephalomyelitis (ME), NAD could offer some alleviation. One of the ways NAD works via the mitochondria is by  boosting the production of ATP. ATP is the primary energy source of all cells in the body.  Boosting NAD levels via IV infusion helps to increase ATP production thereby reducing the severity of chronic fatigue syndromes.

Wondering how you may benefit from NAD supplementation? Give me a call or email and we can discuss how NAD may help you reach your health and wellness goals.


dr_shawn

Patient focused integrative health care. Utilizing effective natural approaches designed to be used alone or to compliment conventional medical care.


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