Immune System – Dr Shawn

29/Jan/2025

In the realm of integrative medicine, Low Dose Naltrexone (LDN) is stepping up as a potential game-changer for serious conditions like cancer and multiple sclerosis (MS). LDN was first used to treat opioid addiction with higher doses. Now, it is being studied for its ability to improve the immune system and reduce inflammation. Early studies have shown some promising results, with patients reporting better quality of life and fewer symptoms. If you’re facing cancer or MS, diving into the potential benefits of LDN could make a real difference. If you’re thinking about this treatment, I’d recommend scheduling a chat with a healthcare provider who can give you personalized advice and support.

Understanding low-dose naltrexone (LDN)

Understanding low-dose naltrexone (LDN) has been a journey of discovery for me. Originally, the FDA approved naltrexone for treating opioid dependence and alcoholism at a standard dose of 50 mg. But here’s where it gets interesting: when the dose is significantly reduced to between 1.5 to 4.5 mg per day, LDN has shown promise in treating conditions like cancer and multiple sclerosis (MS). This change in dose opens up new ways to use integrative medicine. It offers hope and potential benefits that we’re just starting to explore.

The way LDN works is both unique and fascinating. By briefly blocking opioid receptors, it prompts the body to boost the production of natural endorphins. These endorphins are the body’s natural pain relievers and mood lifters. The rise in endorphin levels can strengthen the immune system, which might be why LDN is being studied for conditions like cancer and MS. This enhanced immune activity could help reduce inflammation and improve overall health.

One of the things I love about low-dose naltrexone is how gentle it tends to be on the body. Sure, you might experience some vivid dreams or a bit of tummy trouble, but these side effects are usually pretty easy to handle. The key, though, is to chat with your healthcare provider before diving into LDN. They can offer tailored advice and keep an eye on how you’re responding, making sure you get the best results while keeping any risks at bay.

While research on LDN is still in its early stages, the encouraging findings have ignited a wave of curiosity and a push for more in-depth studies. By diving into how LDN functions and its potential advantages, you can take a more active role in your health journey, making choices that are right for you.

LDN and cancer: What the research shows

As I explore the potential of low-dose naltrexone (LDN), I find myself particularly inspired by its promising role in cancer treatment. Research has indicated that LDN might have anti-tumor properties, which could help slow the growth and spread of certain cancers. This is especially important when considering the limited options available for those dealing with advanced or treatment-resistant cases.

In my journey through the research on low-dose naltrexone (LDN), I’ve come across some truly inspiring stories. Early clinical trials have shown good results. Patients not only see a decrease in the size of their tumors, but also feel better about their lives. The science behind these outcomes is complex, but at its core, it’s about how LDN can fine-tune the immune system. By boosting the body’s natural defenses, LDN may help the immune system more effectively identify and combat cancer cells. This immune modulation is a critical aspect of LDN’s potential as a complementary therapy in cancer treatment.

The early signs are good, but it’s important to know that more big, controlled trials are needed to fully understand how LDN works in cancer treatment. These studies will offer a clearer picture of the treatment’s benefits and risks, helping both patients and healthcare providers make well-informed choices. Even though more research is needed, the good results reported by patients with advanced or treatment-resistant cancer suggest that LDN could be a useful tool in integrative medicine.

If you’re thinking about adding LDN to your cancer treatment plan, it’s crucial to talk to a healthcare provider who can give you personalized advice and keep an eye on your progress. LDN has special properties and can help your immune system. This makes it a good choice for people who want to improve their quality of life and manage their symptoms better.

LDN and Multiple Sclerosis: What the research shows

Moving from the encouraging results in cancer treatment, I’ve also seen low-dose naltrexone (LDN) make waves in the management of multiple sclerosis (MS). Several studies show that LDN can help reduce the number and severity of MS relapses. This gives patients hope because they often have unpredictable and debilitating symptoms. LDN can make a big difference in the quality of life for people with MS by reducing the number of relapses. It can also help them keep a more stable and predictable daily routine.

I’ve found that LDN can really make a difference in the lives of those with MS. Research shows it might boost quality of life and ease fatigue, a symptom that can really wear you down. A 2008 study in the journal “Multiple Sclerosis” highlighted how well-tolerated LDN is and its promising effects on MS symptoms. This, along with other studies, adds to the growing evidence that LDN could be a valuable tool in managing MS.

While LDN isn’t a cure for multiple sclerosis, it has shown promising anti-inflammatory and immune-modulating effects that can be beneficial for MS patients. These effects can help control the long-term inflammation that’s a key part of MS. They can also slow down the disease’s progress and reduce the number of times it comes back. However, more research is needed to fully understand the long-term impacts and the best dosing strategies for LDN in MS. As the field evolves, ongoing studies will continue to shed light on the potential of LDN as a complementary therapy for those living with MS.

Exploring the mechanisms of LDN

Let’s move on from the good research. We’ll look at how low-dose naltrexone (LDN) could be a big help for conditions like cancer and multiple sclerosis (MS). LDN interacts with the body’s opioid receptors, and at these very low doses, it briefly blocks them. This temporary blockage sets off a rebound effect, prompting the body to boost its production of endorphins. These natural chemicals are key players in pain relief and mood improvement.

The boost in endorphin levels is especially noteworthy because it can influence the immune system in a positive way. This interaction is a cornerstone of the potential benefits of LDN. By giving the immune system a lift, LDN can help ease inflammation, a common challenge in conditions like cancer and multiple sclerosis (MS). For those battling cancer, this immune boost might help the body more effectively target and eliminate cancer cells. For MS patients, LDN’s anti-inflammatory effects can help control the long-term inflammation that causes the disease. This could slow down the disease and make flare-ups less common.

Research has also indicated that LDN might offer benefits beyond just modulating the immune system. For example, it has been found to affect the activity of natural killer cells and other immune cells. These cells are important in protecting the body against tumors and infections. These anti-tumor effects highlight LDN’s potential as a complementary therapy in cancer treatment. By understanding these mechanisms, both patients and healthcare providers can make more informed decisions about incorporating LDN into treatment plans. Knowing how LDN works can help individuals weigh its potential benefits and risks, leading to a more personalized and effective approach to their health.

Getting started with LDN: Tips and precautions

As you think about adding low-dose naltrexone (LDN) to your treatment plan, taking a thoughtful and informed approach is key. The first and most important step is to talk to a healthcare provider who has experience with LDN. This conversation can help you decide if LDN is the right fit for your specific condition, like cancer or multiple sclerosis (MS). Your healthcare provider can offer personalized guidance, making sure the treatment aligns with your health goals and medical history.

Starting with a low dose of LDN is a key step in the process. Most patients typically begin with a 1.5 mg dose and slowly work my way up to 4.5 mg over a few weeks. This gradual increase helps keep potential side effects, like insomnia and vivid dreams, at bay. These side effects are common but usually manageable. If you do feel any discomfort, it’s really important to talk to your healthcare provider. They can give you tips to ease these side effects and make sure your treatment stays comfortable and effective.

Regular monitoring plays a crucial role in your LDN journey. Keeping a detailed journal of your symptoms, side effects, and overall health can offer deep insights into how LDN is impacting you. I share this information with my healthcare provider during our regular check-ins. This ongoing dialogue enables my provider to fine-tune my dosage or treatment plan, ensuring I get the most out of LDN.

Thinking about booking a consultation for personalized advice and support as you start your LDN journey? It’s a wise move. A knowledgeable healthcare provider can be your guide, answering your questions and helping you navigate any challenges that come up. By doing these steps, you can make sure your LDN treatment is safe and works. This could help you live a better life and manage your symptoms better.

drshawn

19/Oct/2022

You may have seen posts on social media about the benefits of fasting and how it can help improve immunity, but what does the science say? Is there any truth to these claims? Let’s take a closer look.

There are many different types of fasting diets, but the most common are intermittent fasting, alternate-day fasting, prolonged fasting and fast-mimicking. Some people fast for religious reasons, while others do it for health reasons. Let’s now examine some of the different types of fasting protocols.

Intermittent Fasting

Intermittent fasting is a type of fasting diet where you alternate between periods of eating and not eating, usually for a set number of hours each day.

One popular version of this diet is known as the 16:8 fasting to eating ratio, which involves fasting for 16 hours every day and then consuming all of your food during the remaining 8-hour window. This type of fasting has been shown to have several health benefits, including improved insulin sensitivity, fat loss, and increased longevity.

Alternate Day Fasting

Alternate day fasting is a type of fasting diet in which you alternate between periods of eating and not eating. During the fasting period, you typically consume a very low number of calories, usually less than 500 per day. Some people may choose to fast for 24 hours at a time, while others might fast for two days in a row before returning to normal eating patterns.

There are several potential benefits to this type of diet, including weight loss, improved blood sugar control, and increased longevity. However, there are also some potential risks associated with alternate day fasting, such as nutritional deficiencies and difficulty adhering to the diet over the long term.

Prolonged Fasting

Prolonged fasting is an alternative type of fasting diet that is designed to allow the body to enter into a state of ketosis, a metabolic state in which fat becomes the primary energy source instead of carbohydrates.

Unlike other forms of fasting where the specific timeframe for fasting may vary, prolonged fasting typically involves fasting for 3-5 days at a time with periods of normal eating in between. During this time, people may experience side effects like fatigue, lightheadedness, and hunger pangs.

However, proponents of prolonged fasting claim that this type of fast can help promote weight loss by effectively killing off certain cells in the body that are responsible for storing excess fat. Additionally, some research suggests that prolonged fasting may have other health benefits like improved insulin sensitivity and reduction in inflammation.

Fast Mimicking

The fast mimicking diet is a type of fasting diet that involves consuming specific foods and nutrients in order to mimic the effects of fasting. This approach is typically done over the course of 5 days, during which time people consume a low-calorie diet that is high in nutrients such as vitamins, minerals, and healthy fats. The goal of this type of fast is to trigger certain biological changes that are typically seen during periods of fasting, such as increased insulin sensitivity, reduced inflammation, and enhanced cellular repair.

While there haven’t been many large-scale studies examining the health benefits of fast mimicking diets, early research suggests that they may have a variety of positive effects on health and longevity.

Fasting and Immunity

There is some evidence to suggest that fasting can help boost immunity. One study found that intermittent fasting increased the production of white blood cells, which are your body’s first line of defense against infection. Another study found that alternate-day fasting improved markers of inflammation, which is thought to be involved in the development of some chronic diseases. Fasting also promotes a disease modifying process called autophagy.

Autophagy

Autophagy is a cellular process where the body breaks down damaged or unnecessary parts of cells in order to clear out harmful waste products and repair any damage. This process can be triggered by fasting, which has been shown to increase levels of autophagy throughout the body, helping to protect against disease and promote good health.

Studies have found that intermittent fasting can increase levels of certain proteins involved in the regulation of autophagy, while alternate-day fasting has been shown to induce autophagy even more effectively.

Additionally, researchers believe that fasting may help stimulate the production of stem cells, which are able to replace old or damaged cell tissues and potentially contribute to improved healing and recovery.

Overall, there is strong evidence that fasting can trigger autophagy in various ways, which may help boost immunity and prevent the development of chronic diseases.

Fasting Risks

It’s important to note that fasting is not for everyone. If you have a medical condition or are taking medication, please consult with your healthcare provider before starting any type of fasting diet. Fasting can also be dangerous if not done correctly. For example, if you don’t eat enough calories or nutrients, you may experience fatigue, irritability, and difficulty concentrating. You may also be at risk for dehydration if you are not drinking enough fluids.

Conclusion

So, should you start fasting to improve your immunity? Personally, fasting is the first thing I do when I feel a cold or flu coming on. I have found that this practice dramatically reduces symptoms and duration of illness. As you can see there is some research to support fasting as a natural immune system booster. It is important to note that fasting is not for everyone and can be dangerous if not done correctly. If you’re thinking about starting a fasting diet, please consult with your healthcare provider first.

drshawn

30/Jun/2022

What is Long Covid?

Long Covid is defined as symptoms that present 12 weeks after infection and that persist for at least 8 weeks. The most common symptoms being: Fatigue, Shortness of Breath and Cognitive Dysfunction. There will be an estimated 150 million cases of Long Covid cases worldwide as of 2022. Long Covid has the potential to significantly impact the lives of a large portion of the population making day to day activities difficult or near impossible. Although there are ways to reduce the risk factors in developing long covid, there aren’t many proven conventional medications to treat Long Covid once symptoms set in.

We now know that viral fragments, lingering spike protein and persistent inflammation are all likely features of Long Covid. This chronic state of immune activation leads to heart and blood vessel abnormalities, lung impairment, neurological injury and autoimmunity. Luckily, functional medicine practitioners have been at the forefront in developing protocols that work to resolve the aftermath of COVID-19 infection.

Mitochondrial Dysfunction

There is evidence of mitochondrial dysfunction in Long Covid cases as seen through disruption in fatty acid oxidation and altered lactate production. This would also partially explain the chronic fatigue of Long Covid. Functional medicine has a long history of developing protocols to address mitochondrial dysfunction. Many of the compounds used have been showing promise in treating Long Covid. For example, there is evidence of reduced levels of Coenzyme Q10 in COVID-19 infection. CoQ10 is an important compound in mitochondrial function and energy production. Supplementing with this compound along with other mitochondrial supportive nutrients (Niacin, N-Acetyl Cysteine, Alpha Lipoic Acid) have been helpful in treating Long COVID associated fatigue.

Chronic Inflammation

We also know that there is a wealth of data to suggest high levels of inflammatory markers in Long Covid sufferers. Conventionally, steroids such as prednisone have been used to effectively treat Long Covid symptoms. However, steroids can not be used indefinitely as there are significant side effects associated with long term usage. In Naturopathic and Functional Medicine we have evidence of a number of naturally derived compounds that work to treat Long Covid associated inflammation including: Curcumin, Resveratrol, Cannabinoids, Luteolin, Omega 3, and Black Cumin.

Immune System Abnormalities

We also know that there is immune system dysfunction in Long Covid as evidenced in abnormal T-cell behaviour. One of the most important compounds regulating immune function is vitamin D. There is strong evidence that having adequate vitamin D status prior to Covid infection is protective toward Long Covid and giving large doses of vitamin D to both active Covid-19 cases and Long Covid sufferers can be therapeutic.

Gastrointestinal Symptoms

Long Covid cases also seem to have a higher incidence of prolonged gastrointestinal symptoms and intestinal dysbiosis with organisms that increase inflammation. One of the best ways to treat intestinal inflammation is by promoting the growth of intestinal organisms that produce the short chain fatty acid Butyrate. Food that is high in fibre typically help to promote beneficial species of intestinal organisms. Oats, Apples, Onions, Asparagus, Broccoli, Whole grains, underripe bananas, Legumes, and Berries are some excellent foods shown to promote butyrate production.

Cannabinoids

Cannabinoids, and more specifically cannabidiol (CBD) has been shown to have some interesting mechanisms in the treatment of Long Covid. Strains of cannabis containing high levels of CBD have been shown to block spike protein from entering the cell (via ACE-2 receptors), modulate ACE-2 receptor density on cell surfaces (less doors of COVID to enter) and reduce inflammation. Therefore cannabinoids are very exciting compounds currently being investigated for use in Long Covid therapy.

Conclusions

Long Covid is a multifaceted chronic disease with effects on various physiological systems. Drugs with a narrow therapeutic scope are not going to be as effective as complex compounds that effect multiple physiological processes at the same time. This type of therapeutic synergy is a hallmark of naturally derived medicines and therefore functional medicine is going to play a pivotal role in dealing with this prevalent and highly complex disease state. In my Toronto practice I have had several cases of long covid that only began to resolve once a functional medicine protocol was put into place. So if you know someone who is suffering from Long Covid I recommend connecting them with a local Naturopathic Doctor or Functional Medicine Practitioner.

DoctorShawn

31/Aug/2018

Multiple Sclerosis is a complex disease; those living with it need a simple approach. A treatment approach should appreciate the physiology of the disease process without neglecting the human body as a holistic system, and the patient as a person.

Naturopathy is an ideal philosophy of medicine for the treatment of M.S. as it aims to address disease processes and symptoms without loosing sight of the patient as an individual.

I chose to focus in neurological disease early into my professional career and as a result I have come across many complex chronic diseases of the nervous system including all subtypes of M.S. When patients come for their initial visit it is not uncommon to be privy to a long list of life events that have impacted the disease, symptoms that have evolved over years and medications that have been tried, stopped and tried again.

It’s easy to see why the practitioner on the other end of the patient with M.S. can become overwhelmed and confused, loosing sight of the big picture, dismissing the patients needs and goals. Unfortunately, this medical tunnel vision re-aimed at addressing each and every concern translates into complex and confusing treatment plans that most patients cannot comply with. I sympathize with these patients who have to remember to take dozens of pills while also dealing with a life altering condition.

To make matters worse, these confusing treatment plans hardly ever work because they tend to forget that the human body is not a series of islands, rather it’s a society striving to work in harmony and balance. The key to developing a simple, understandable and effective treatment plan is to figure out what is out of balance and how do we bring it back.

A typical treatment plan for M.S. has three parts: Foundations, The Immune System and Specific Symptoms. Since we are working toward bringing the body back into balance it is important to take the time to hear the full story and timeline of how the condition started and progressed. Often during the initial consultation it will become clear as to what type of events precluded the first attack and how these events triggered a physiological imbalance.

Foundations

It’s a futile effort to try and treat symptoms while the very basics of health and wellness are not fortified. The foundations of health can be summed up into three parts: Sleep, Diet and Exercise.

Sleep is the healing chamber for the body. Recently studies have shown that the brain undergoes a type of detoxification process while we sleep. Many neurodegenerative diseases have been correlated to poor sleeping habits. It is common to see sleeping issues in patients with M.S. In fact I have had a few cases where years of terrible sleep may have contributed to the patient experiencing their first symptoms related to M.S. This makes sense in the light of the new research demonstrating how important sleep is in clearing neurotoxic compounds from the brain.

One of the most important protocols I put together for my M.S. patients is aimed at improving sleep. This is achieved through sleep hygiene education and supplements that have been carefully vetted over my years in practices for their effectiveness in improving sleep initiation and maintenance.

Diet is important for a number of reasons, some are general and some are specific to M.S. The food we eat and its relation to our digestive tract determines our nutritional robustness.

M.S. is a chronic neuro-inflammatory state and therefore patients with M.S. will be using up vitamins and minerals involved in inflammatory processes at a greater rate than in a healthy control group. Therefor it’s important to determine what the nutritional status is of the M.S. patient (through consultation and specific lab tests), bring it back into balance and correct deficiencies. Otherwise the body will be unable to cope with the inflammatory process and the disease will progress.

It is also important to identify any food allergens, intolerances and sensitivities in the M.S. patient for these will perpetuate the inflammation. Chronic inflammation has a detrimental effect on the immune system, which I will discuss further in the next part of the treatment plan.

Another aspect related to diet is the health of the gastrointestinal tract and more specifically the micro-biome (the bacteria of the gut). A healthy micro-biome is important for detoxification, nutrient absorption and immune system regulation. A protocol addressing diet will focus on testing for nutritional deficiencies, food sensitivities, specific dietary guidelines for M.S. and supportive supplements where necessary.

A good dietary resource specific to M.S. is The Wahls Protocol.

Exercise is a powerful health modulator and is under-appreciated for its importance in chronic disease and specifically M.S. Often exercise comes in the form of physiotherapy in progressive M.S. and the first thing I will do with a patient is set them up with one of the physiotherapists in my clinic (if they don’t already have a physiotherapy program). Often patients newly diagnosed with M.S. are neglected by the medical system in terms of exercise. In-patient rehab programs are inadequate, scooters and wheelchairs are promoted over therapy. Exercise and physiotherapy are instrumental in promoting neuroplasticity, decreasing inflammation, improving energy metabolism, maintaining and improving upon range of motion.

My clinic specializes in neurological rehabilitation using the Bobath Physiotherapy approach. Physio-Logic

The Immune System

Multiple Sclerosis is an autoimmune condition and therefore one cannot overlook the role of the immune system. Autoimmunity basically translates to a confused immune system that has targeted healthy cells and tissues rather than disease. The philosophy behind this part of the treatment plan addresses two questions: how the immune system became confused and how to bring it back into harmony.

There are many theories as to the cause of M.S., to name a few: Genetics, Vitamin D deficiency, Environmental Toxin Exposure, Candida Overgrowth, Dairy Protein Antigen Confusion and Leaky Gut Syndrome. There are truths to be told within many of these theories but in reality we just don’t know exactly what causes M.S. Some things we do know are the triggers for symptom activation, and things that reduce the risk of developing M.S. We know that stress (physical and/or emotional) often precipitate symptom relapse and progression. We also know that having adequate vitamin D levels are protective toward the development of M.S.

Vitamin D is not longer thought of as merely a bone-building vitamin. In reality it is more of a hormone and has a very important role in maintaining the health of the immune system. Step one of addressing the immune system is making sure the patient has optimal levels of vitamin D and if not, to adjust those levels using specific supplemental doses of vitamin D along with calcium and regular follow-up blood work.

Stress, whether it physical or emotional, causes a burden on the body. Most of the time we are able to cope with short durations of stress; however, when the stressful event is severe enough or lasts long enough it can impact the immune system in a negative way. Chronic stress can affect the immune system in two ways: Creating chronic inflammation that harms tissues and suppressing immune cells needed to fight infection.

When the immune system is under prolonged stress it becomes tired and makes mistakes, much like how we feel when under stress. One of these possible mistakes is mounting an autoimmune attack, harming normal healthy tissue rather than disease. Prolonged stress also depletes natural anti-inflammatory compounds like cortisol, allowing inflammation to run amuck. Therefore the protocol built around the immune system is aimed at decreasing stress on the immune system and bringing the immune system back into balance.

Anything that can be causing unnecessary inflammation needs to be dealt with and therefore chronic infections and food sensitivities must be addressed. Specific lab testing is used to investigate infections and sensitivities. Common food sensitivities in M.S. patients include: Dairy, Gluten, Yeast and Egg.

Once the major obstacles to a healthy immune system are removed we can work toward assisting the immune system back into a balanced state. The most important cells involved in bringing the immune system back into balance are “regulatory T cells” also known as “T suppressor cells”. These cells maintain tolerance in the immune system preventing autoimmunity. Part of the protocol is therefore aimed at supporting these cells. Some compounds that influence regulatory T cells are: probiotics, vitamin D, vitamin A, Omega 3 fatty acids and food sensitivities.

Specific Symptoms

Treating foundations and immune system irregularities take time, therefore it is almost equally important to address the specific symptoms of the patient. Fatigue, weakness and pain are often obstacles to important foundational concerns like sleep and exercise.

Fortunately, there are many great strategies within Naturopathic medicine to help address the most common symptoms in M.S. namely: Weakness, Spasticity, Fatigue, Pain, Bowel and Bladder issues. There are dozens of supplements that have shown promise in treating the common symptoms of M.S. The art of the practitioner is in choosing the right compounds for the right patient. As an example, medical marijuana can be very effective for spasticity, pain, bladder dysfunction and sleep but can exacerbate weakness. A good practitioner with experience in treating M.S. will know how to choose the appropriate medications for the patients needs.

Multiple Sclerosis is a complex condition with many subtypes and many different ways it affects the individual patient. Naturopathic medicine aims to treat the root cause of disease while also addressing the individual concerns of the patient. The treatment plan can be summed up into three areas: Foundations, Immune System and Specific Symptoms. This helps direct the practitioner toward the right approach and simplifies the philosophy behind the treatment, improving upon compliance and therefore patient outcomes.

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Low Dose Naltrexone for Cancer and Multiple Sclerosis