Introduction:
October means apple season is in full swing. And while apples are delicious and a great source of fiber, they also have some surprising health benefits. Here are 5 reasons to make sure you include apples in your diet this fall.
1. Apples Can Boost Your Immunity
One of the essential components of a strong immune system is vitamin C, and apples are packed with it. Just one small apple contains approximately 10% of your daily recommended intake of vitamin C. Vitamin C is a powerful antioxidant that helps protect your cells from damage and supports a healthy immune system.
Apples are also a good source of vitamin A, which is important for a strong immune system. Vitamin A helps the body’s natural defenses against infection and disease. It also helps to keep the skin and mucous membranes healthy. The body needs vitamin A to form white blood cells, which help to fight infection. Vitamin A is found in both the skin and the flesh of apples, so eating a whole apple is the best way to get the benefits.
In addition, apples contain polyphenols, which are plant-based compounds that have been shown to boost immunity.
Apples contain a type of polyphenol called quercetin. Quercetin is a plant-based compound that has been shown to provide a number of health benefits, including boosting the immune system. One study found that quercetin supplements were able to increase the production of infection-fighting cells in the body. Another study found that quercetin supplements were able to reduce the severity and duration of cold symptoms. Polyphenols like quercetin are just one of the many reasons why apples are often referred to as a “superfood.”
2. Apples Can Help Reduce the Risk of Diabetes
Type 2 diabetes is a serious and growing health concern, with over 29 million Americans affected by the disease. Eating apples has been linked with a lower risk of type 2 diabetes. This is likely due to the fact that apples contain pectin. Pectin helps to slow the digestion and absorption of carbohydrates, which helps to keep blood sugar levels stable. Additionally, apples are a good source of antioxidants, which can help improve insulin sensitivity.
3. Apples May Help Lower Cholesterol Levels
One large apple contains about 4 grams of fiber, half of which is pectin. Pectin has been shown to reduce cholesterol levels by binding to cholesterol molecules and removing them from the body before they can be absorbed into the bloodstream.
Research has supported the notion that apples can help reduce cholesterol levels. One study showed that eating two apples a day for four weeks resulted in a seven percent reduction in bad cholesterol and a five percent increase in good cholesterol. Another study found that women who ate an apple a day had lower cholesterol levels and a decreased risk of heart disease. The antioxidants and fiber in apples are thought to be responsible for these benefits.
4. Apples Can Help Keep Your Heart Healthy
In addition to reducing cholesterol levels, apples can also help keep your heart healthy by preventing plaque build-up in your arteries. This is thanks to the antioxidants found in apples, which help keep your arteries clear and prevent inflammation. One study published in the “European Journal of Nutrition” showed that eating apples every day for four weeks can reduce bad cholesterol levels by up to 10 percent.
5. Apples Can Aid in Weight Loss
Because they’re high in fiber and water, apples can help you feel fuller longer and prevent overeating throughout the day. 
Research indicates that apples may play a role in weight loss. One study showed that obese women who ate an apple before lunch felt more satiated and ate fewer calories than those who didn’t have an apple. Another study found that eating an apple at least three times per day helped participants lose weight and body fat. This may be due to the high fiber and water content of apples, which can help you feel fuller longer and prevent overeating. Additionally, apples are a low calorie food, providing just 95 calories per medium-sized apple. They’re also a good source of energy-boosting phosphorus.
Conclusion:
The next time you’re at the grocery store, be sure to pick up a few extra apples. Not only are they delicious and nutritious, but they also have some impressive health benefits. Apples can boost your immune system, lower your cholesterol levels, and even help you live longer. So stock up while they’re in season and enjoy all the benefits this versatile fruit has to offer.
Introduction
Manuka honey is a type of monofloral honey that is derived from the nectar of the manuka tree. This honey has been used for centuries for its medicinal properties. In recent years, it has become increasingly popular as a natural remedy for a wide variety of ailments. But with so many different types and brands of Manuka honey on the market, how do you know which one to choose?
MGO and K Factor
When it comes to choosing the best Manuka honey, there are a few things you need to keep in mind. First, you need to make sure that you are buying pure Manuka honey. This means that the honey should be sourced from bees that have only collected nectar from the manuka tree. Second, you need to look for a brand that clearly labels the methylglyoxal (MGO) content of their honey. MGO is a compound found in Manuka honey that is responsible for its antibacterial properties. The higher the MGO content, the more potent the antibacterial effects will be.
MGO is not the only compound responsible for the antibacterial properties of Manuka honey. The K factor and UMF rating is another measure of the potency of Manuka honey that takes into account the total number of methylglyoxal molecules in a given sample of honey. The higher the K factor or UMF, the more potent the antibacterial effects will be.
Type of application
Finally, you need to decide what type of Manuka honey you want. There are three main types of Manuka honey: Active, medical-grade, and cosmetic-grade. Active Manuka honey is typically used topically to treat wounds or skin infections. Medical-grade Manuka honey is sterile and can be used directly on open wounds. Cosmetic-grade Manuka honey is suitable for use in skincare products and can be used to help improve skin texture and tone.
What to use it for?
There are a number of different conditions that Manuka honey can be used to treat. Some of the most common include:
-Infections:
Manuka honey has natural antibacterial and antifungal properties that make it effective against a variety of infections. It can be used to treat everything from minor skin infections to more serious illnesses like pneumonia.
-H.Pylori:
Manuka honey has been shown to be effective against H.Pylori infection and gastric ulcers. A study published in the journal “BMC Complementary and Alternative Medicine” found that Manuka honey was able to inhibit the growth of H.Pylori bacteria. Additionally, a study published in the journal “Digestive Diseases and Sciences” found that Manuka honey was able to improve symptoms of gastric ulcers.
-Allergies:
Manuka honey has been shown to be effective in treating allergies. It helps to reduce inflammation and congestion, and can also help to soothe irritated throats.
-Digestive problems:
Manuka honey is a natural probiotic, meaning it helps to promote healthy digestion. It can be helpful in treating a variety of digestive problems, such as constipation, diarrhea, and indigestion.
-Wound healing:
Manuka honey has been shown to speed up wound healing times, both internally and externally. It helps to reduce inflammation and bacteria levels at the wound site, which can promote faster healing.
Conclusion:
The three things to look for when purchasing Manuka honey are purity, MGO content, and type. Manuka honey is effective for a variety of conditions, such as infections, allergies, digestive problems, and wound healing. Buying a honey that has been certified as pure and has a high MGO content will ensure that you’re getting the best possible product for your needs.
Multiple sclerosis is a debilitating neurological disorder that can often leave patients feeling hopeless and alone. But there is hope! In this blog post, we will explore nine natural treatments for multiple sclerosis that have helped my Toronto patients alleviate some of the symptoms associated with the disease.
1. Acupuncture
Acupuncture is a traditional Chinese medicine technique that involves inserting thin needles into the skin at specific points on the body. It is believed that this helps to clear energy blockages and promote balance and healing within the body. There is some evidence to suggest that acupuncture may be effective in treating symptoms of multiple sclerosis, such as fatigue, pain, spasticity, and bladder problems.
2. Herbal Medicine
There are many different herbs that have been traditionally used to treat various ailments, including multiple sclerosis. Some of the most common herbs used for MS include ginger, ginkgo biloba, turmeric, milk thistle, lions mane and green tea. These herbs can be taken in pill form or brewed into a tea. It is important to talk to a Naturopathic Doctor or qualified herbal practitioner before starting any herbal treatment regimen, as some herbs can interact with medications you may be taking for your MS.
3. Dietary Changes
Making some simple dietary changes can also help improve symptoms of MS. One study showed that following a Mediterranean diet—which includes lots of fresh fruits and vegetables, whole grains, fish, and olive oil—may help reduce inflammation and slow the progression of MS. Other helpful dietary changes include avoiding processed foods and food allergies, getting enough vitamin D, and drinking plenty of water.
Food sensitivity testing can help to identify gluten sensitivity and other food sensitivities in people with MS and other autoimmune diseases. The most common type of food sensitivity test is an Elimination Diet, in which potential triggering foods are eliminated from the diet for a period of time and then reintroduced one at a time to see if symptoms occur. However, Elimination Diets can be difficult to stick to and can take months or even years to complete. Another option is an IgG Food Sensitivity Test, which measures levels of immunoglobulin G (IgG) antibodies in the blood.
Antibodies are produced by the immune system in response to perceived threats, such as bacteria or viruses. However, in people with food sensitivities, the immune system overreacts to harmless proteins found in certain foods, producing excessive amounts of IgG antibodies. IgG Food Sensitivity Tests can be helpful in identifying food sensitivities because they can measure levels of IgG antibodies specific to each individual food protein. This allows for a more targeted Elimination Diet and can speed up the diagnosis process. If you think you might have a food sensitivity, you can book an appointment for testing.
4. Exercise
Exercise is important for everyone, but it is especially crucial for those with MS. Regular physical activity can help reduce fatigue, improve mobility and coordination, ease depression and anxiety, promote better sleep, and boost overall fitness and well-being. Even if you are not able to do strenuous exercise due to your symptoms, there are still many low-impact activities you can do to get moving and feeling better.
5. Stress Reduction Techniques
Stress is a well-known trigger for multiple sclerosis (MS) flare-ups. Managing stress is therefore an important part of MS treatment. Stress management techniques such as relaxation therapy and yoga can be helpful, but some patients may also benefit from taking adaptogens. Adaptogens are a class of natural substances that help the body to adapt to stress by reducing the production of stress hormones. They have been used for centuries in traditional Chinese and Indian medicine, and are now gaining popularity as a natural treatment for stress and anxiety. Some common adaptogens include ashwagandha, holy basil, and ginseng. If you are interested in trying adaptogens, talk to your Naturopathic doctor first to discuss whether they are right for you.
6. Vitamin D
Vitamin D is an important nutrient that helps the body absorb calcium. It’s found naturally in very few foods, so most people get it from exposure to sunlight. Vitamin D is also available in supplement form. Some studies suggest that vitamin D may play a role in helping to prevent or treat MS. If you think you might be deficient in vitamin D, book an appointment with us for vitamin D testing or talk to your doctor.
Sometimes supplementation is ineffective or can take too long to bring up severely deficient vitamin D levels. I offer these patients the option of a high potency vitamin D injection that will bring levels up very quickly.
7. Mitochondrial Support
Mitochondrial support using resveratrol, alpha lipoic acid, coenzyme Q10 and NAD boosters is a promising new treatment for patients with multiple sclerosis. Mitochondria are the powerhouses of the cell, and they are responsible for producing energy. In patients with multiple sclerosis, the mitochondria are not working properly, and this can lead to fatigue and other symptoms. Resveratrol, alpha lipoic acid, coenzyme Q10 and NAD boosters help to support the mitochondria and improve their function. In a small study of patients with multiple sclerosis, those who received mitochondrial support had less fatigue and improved quality of life.
8. Hormones
Hormones play an important role in the human body, regulating everything from metabolism and mood to reproduction and energy levels. When hormones are out of balance, it can lead to a host of problems. For patients with multiple sclerosis (MS), hormone imbalances can cause fatigue, weight gain, depression, and loss of libido. Hormone testing can help to identify imbalances and allow for tailored treatment plans that use bio identical hormone replacement therapy to restore balance. By addressing hormone imbalances, patients with MS can improve their quality of life and potentially reduce their risk of disease progression.
9. Cannabinoids
Recently, cannabinoids have emerged as a potential therapy for MS. Cannabinoids are compounds found in the cannabis plant, and they have been shown to have anti-inflammatory and neuroprotective effects. In animal studies, cannabinoids have been shown to reduce inflammation and nerve damage in models of MS. In small clinical trials, cannabinoids have been shown to improve symptom control in patients with MS. These promising results have led to the development of several cannabinoid-based medications for MS. Dr. Shawn Meirovici N.D. is experienced cannabis educator in Toronto, Ontario. Dr. Shawn can help patients decide if cannabis therapy would be a good addition to their treatment plan.
Conclusion:
If you are living with multiple sclerosis (MS), know that you are not alone—there are millions of other people around the world dealing with this disease every day. And while there is no cure for MS at this time, there are many different treatments that can help alleviate some of the symptoms associated with the disease. In this blog post, we explored nine natural treatments for MS—acupuncture , herbal medicine , dietary changes , exercise , stress reduction techniques, vitamin D, mitochondrial support, hormone balancing and cannabinoid therapy. Make an appointment with us or talk to your doctor about which treatments might be right for you.
Do you feel like you’re always getting sick? Are you constantly battling colds and the flu? If so, you may need to boost your immunity. Luckily, there are a number of natural treatments that can help. In this blog post, we will discuss some of the best ways to improve your immune system naturally.
Vitamin D for immunity
Vitamin D is essential for a strong immune system. It helps the body to produce antibodies, which fight infection. Vitamin D can be found in fatty fish, eggs, and fortified milk. You can also get Vitamin D from exposure to sunlight.
Trouble keeping up with vitamin D supplements and worried about sun exposure? Not to worry, at my clinic we offer the option of a vitamin D injection. Under professional supervision, this is a safe and effective way to boost vitamin D levels quickly.
Vitamin C for immunity
Another important nutrient for immunity is Vitamin C. Vitamin C helps the body to create white blood cells, which fight infection. Vitamin C can be found in citrus fruits, tomatoes, bell peppers, and broccoli.
Intravenous vitamin C is a great way to get a high dose of Vitamin C. By bypassing digestion, IV vitamin C can boost levels quickly. Intravenous vitamin C can also increase blood concentrations at levels that directly kill pathogens and inhibit cancer growth.
Zinc for immunity
Zinc is another important mineral for immunity. It helps the body to create new cells and enzymes that fight infection. Zinc can be found in oysters, beef, pork, chicken, and beans.
Zinc can also be added to intravenous infusions for an added immune system boost.
Elderberry Syrup
If you’re looking for a kid friendly and great tasting way to boost your immunity, elderberry syrup is a great option. Elderberries are rich in Vitamin C, Vitamin A, and antioxidants. They have been shown to reduce inflammation and fight infection. You can find elderberry syrup at most health food stores.
Ginger for immunity
Ginger is another great option for boosting your immunity. Ginger is a natural anti-inflammatory and can help to reduce congestion. It can also help to soothe a sore throat. You can find ginger in the form of capsules, tea, or syrup.
Garlic for immunity
Garlic is another excellent food for boosting your immunity. Garlic is rich in Vitamin C, sulfur, and antioxidants. It has been shown to fight infection and reduce inflammation. You can add garlic to your food or take it in supplement form.
Selenium for immunity
Selenium is a trace mineral that is important for immunity. Selenium helps the body to produce antibodies, which fight infection. It can be found in Brazil nuts, tuna, shrimp, and eggs.
Selenium can also be added to an intravenous infusion for an added immune boost.
Vitamin A for immunity
Vitamin A is an important nutrient for immunity. Vitamin A helps the body to produce white blood cells, which fight infection. Vitamin A can be found in sweet potatoes, carrots, dark leafy greens, and squash.
Probiotics for immunity
Probiotics are live bacteria that are good for your gut health. Probiotics help to keep the balance of good and bad bacteria in your gut. This can help to improve digestion and boost immunity. You can find probiotics in yogurt, kimchi, sauerkraut, and kombucha.Probiotic supplements are also available.
There you have it! These are just a few of the best ways to boost your immunity naturally. By including these foods and supplements in your diet, you can help to keep yourself healthy and avoid getting sick. In individuals requiring an extra boost, injection and intravenous treatments are available and effective. Do you have any other favourite natural immunity boosters? Share them with us in the comments
What is Long Covid?
Long Covid is defined as symptoms that present 12 weeks after infection and that persist for at least 8 weeks. The most common symptoms being: Fatigue, Shortness of Breath and Cognitive Dysfunction. There will be an estimated 150 million cases of Long Covid cases worldwide as of 2022. Long Covid has the potential to significantly impact the lives of a large portion of the population making day to day activities difficult or near impossible. Although there are ways to reduce the risk factors in developing long covid, there aren’t many proven conventional medications to treat Long Covid once symptoms set in.
We now know that viral fragments, lingering spike protein and persistent inflammation are all likely features of Long Covid. This chronic state of immune activation leads to heart and blood vessel abnormalities, lung impairment, neurological injury and autoimmunity. Luckily, functional medicine practitioners have been at the forefront in developing protocols that work to resolve the aftermath of COVID-19 infection.
Mitochondrial Dysfunction
There is evidence of mitochondrial dysfunction in Long Covid cases as seen through disruption in fatty acid oxidation and altered lactate production. This would also partially explain the chronic fatigue of Long Covid. Functional medicine has a long history of developing protocols to address mitochondrial dysfunction. Many of the compounds used have been showing promise in treating Long Covid. For example, there is evidence of reduced levels of Coenzyme Q10 in COVID-19 infection. CoQ10 is an important compound in mitochondrial function and energy production. Supplementing with this compound along with other mitochondrial supportive nutrients (Niacin, N-Acetyl Cysteine, Alpha Lipoic Acid) have been helpful in treating Long COVID associated fatigue.
Chronic Inflammation
We also know that there is a wealth of data to suggest high levels of inflammatory markers in Long Covid sufferers. Conventionally, steroids such as prednisone have been used to effectively treat Long Covid symptoms. However, steroids can not be used indefinitely as there are significant side effects associated with long term usage. In Naturopathic and Functional Medicine we have evidence of a number of naturally derived compounds that work to treat Long Covid associated inflammation including: Curcumin, Resveratrol, Cannabinoids, Luteolin, Omega 3, and Black Cumin.
Immune System Abnormalities
We also know that there is immune system dysfunction in Long Covid as evidenced in abnormal T-cell behaviour. One of the most important compounds regulating immune function is vitamin D. There is strong evidence that having adequate vitamin D status prior to Covid infection is protective toward Long Covid and giving large doses of vitamin D to both active Covid-19 cases and Long Covid sufferers can be therapeutic.
Gastrointestinal Symptoms
Long Covid cases also seem to have a higher incidence of prolonged gastrointestinal symptoms and intestinal dysbiosis with organisms that increase inflammation. One of the best ways to treat intestinal inflammation is by promoting the growth of intestinal organisms that produce the short chain fatty acid Butyrate. Food that is high in fibre typically help to promote beneficial species of intestinal organisms. Oats, Apples, Onions, Asparagus, Broccoli, Whole grains, underripe bananas, Legumes, and Berries are some excellent foods shown to promote butyrate production.
Cannabinoids
Cannabinoids, and more specifically cannabidiol (CBD) has been shown to have some interesting mechanisms in the treatment of Long Covid. Strains of cannabis containing high levels of CBD have been shown to block spike protein from entering the cell (via ACE-2 receptors), modulate ACE-2 receptor density on cell surfaces (less doors of COVID to enter) and reduce inflammation. Therefore cannabinoids are very exciting compounds currently being investigated for use in Long Covid therapy.
Conclusions
Long Covid is a multifaceted chronic disease with effects on various physiological systems. Drugs with a narrow therapeutic scope are not going to be as effective as complex compounds that effect multiple physiological processes at the same time. This type of therapeutic synergy is a hallmark of naturally derived medicines and therefore functional medicine is going to play a pivotal role in dealing with this prevalent and highly complex disease state. In my Toronto practice I have had several cases of long covid that only began to resolve once a functional medicine protocol was put into place. So if you know someone who is suffering from Long Covid I recommend connecting them with a local Naturopathic Doctor or Functional Medicine Practitioner.
Intro
Our world is facing an epidemic of Long COVID over the next decade. Assuming at least 10% of COVID-19 survivors develop long COVID, which is likely underestimated, it is estimated that 5 million people are facing long COVID globally. Long COVID affects multiple systems in the body and therefore requires a multidisciplinary approach. It is a shared opinion amongst several specialists that a functional medicine approach will be needed to rehab these patients back to health. While we are still in the beginning stages of understanding this chronic disease, there are some emerging ideas on how to treat Long COVID as well as some nutritional supplements that may offer a complete or partial solution.
Defining Long Covid
The now accepted technical name for Long Covid is Post Acute Sequelae of CO-V-2 (PASC). While a widely accepted definition is lacking, there seems to be some consensus on the approximate timing of symptoms and the type of symptoms common to a diagnosis of PASC. Onset is typically anywhere from 2-8 weeks after a confirmed or suspected COVID-19 infection and may persist up to 6-months or more. Common symptoms include: fatigue, dyspnoea (shortness of breath), cognitive dysfunction, headache, myalgia, chest pain, joint pain, smell and taste dysfunction, cough, hair loss, insomnia, wheezing, rhinorrhea, autonomic dysfunction (POTS), cardiac and gastrointestinal issues.
Risk Factors
Some of the clearly defined risk factors for developing long COVID include: More than 5 initial symptoms, initial disease severity, female sex, pre-existing comorbidity, prior psychiatric disorder, and old age. There are also certain biomarkers in blood samples that appear to have a correlation with Long COVID including: Increased levels of D-dimer, CRP, IL6, procalcitonin, troponin-1, BUN, neutrophils and decreased levels of lymphocytes.
Pathophysiology
Although the exact mechanisms behind what causes PASC in not completely understood recent research has pointed towards a few mechanisms. For some Long Covid sufferers there seems to be evidence of long term tissue damage in the cardiovascular, pulmonary and neurological systems. There is also prevalence of unresolved inflammation, viral persistence, gut dysbiosis and autoimmunity.
Treatments
The obvious question that everyone would like know is if there are treatment interventions to both prevent and alleviate the symptoms of PASC. The most conventionally accepted treatments thus far are: Personalized rehabilitation programs (light aerobic and breathing exercises), analgesics, antidepressants, ivabradine (for POTS like symptoms) and antihistamines. It is also accepted that treatment to regulate immune and mitochondrial function would be useful. This is perhaps where naturopathic and functional medicine can make an enormous impact.
There is emerging research looking into nutraceutical compounds to help prevent and treat PASC, here is an overview:
Mitochondrial Support: The mitochondria is an energy producing organelle within every cell of our body. In high school science we are taught that the mitochondria is the “power plant of the cell”. Disruptions in mitochondrial function can lead to fatigue, muscle pain, headache and immune dysfunction. COVID-19 infections seems to disrupt mitochondrial function through mechanisms still being investigated but include oxidative stress and alterations in genetic mutation.
Co-factor nutrients that help support mitochondrial function are being investigated for use in treating COVID-19 infection and PASC. These nutrients include: L-Carnitine, Alpha lipoic acid and Coenzyme Q10. A CoQ10 deficiency has been reported in COVID-19 patients and therefore supplementation with this particular compound is of great interest amongst researchers.
Inflammation: Inflammation seems to be driving a lot of the symptomatology in PASC. Inflammatory compounds have been identified in multiple organ systems including the brain, lungs, pancreas and heart. As such one natural anti-inflammatory compound has been identified as being a possible adjuvant therapy in both COVID-19 infection and PASC.
Curcumin is a compound derived from Turmeric and has anti-inflammatory, anti-viral, anticoagulant, anti-platelet and cytoprotective properties. There has been some evidence to suggest that 1000mg of a turmeric supplement restored smell and taste in individuals who lost these senses following COVID-19 infection. Furthermore in vitro studies have demonstrated that curcumin can inhibit coronavirus from entering the cell, and can disrupt some of the signing processes of the virus.
Immune System: Many of the complications of COVID-19 can be attributed to a dysfunctional response of the immune system, either over-reactive or under-reactive. Many compounds that have a direct and indirect role in proper immune system activity are showing promise in treating COVID-19 infection and PASC.
Vitamin D acts as an immune activity regulator, helping to both increase and decrease immune activity as is appropriate to the situation. Some studies have demonstrated that vitamin D supplementation after COVID-19 infection is associated with less ICU admissions and decrease mortality. Another study demonstrated that a combination of vitamin D, selenium and zinc was able to mitigate the course of respiratory complications with COVID-19 infection. It is likely that co-factors and nutrients which help support normal immune activity can shorten the duration of PASC and alleviate symptoms.
Gastrointestinal: Symptoms affecting the gastrointestinal tract are both common in COVID-19 infection and PASC. There is evidence that COVID-19 and its associated spike protein can persist in the gastrointestinal tract for months after confirmed infection.
Autoimmune type syndromes are commonly seen with PASC. One hypothesis for this outcome is a type of molecular mimicry between spike protein and healthy tissue. Spike protein can enter through a compromised digestive tract into the blood stream. Once in the blood stream the immune system can create auto-antibodies in response.
Maintaining a healthy gut/body barrier is emerging as a possible area of treatment in COVID-19 infection and PASC. A healthy environment of commensal bacteria strengthens the gut/body barrier as well as driving the production of healing compounds such as butyrate.
Butyrate is a short chain fatty acid that is produced by beneficial bacteria in our gastrointestinal tract. Butyrate can cross the blood brain barrier and influence regeneration of damaged nerve cells. Probiotic strains belonging to the Lactobacillus and Bifidobactrium categories are
essential for Butyrate production. While probiotic supplementation can assist in developing a healthy gut environment most of the benefit comes from eating foods which help these probiotics thrive. A diet rich in fibre and polyphenols is therefore essential in influencing the growth of beneficial butyrate producing probiotics. Fruit, veggies, and polyphenols like curcumin, luteolin and resveratrol are likely an important part of what will be a holistic approach to treating PASC.
Conclusions: The COVID-19 virus has turned out to be a multifaceted disrupter of homeostasis in a large percentage of those who have been infected. A functional medicine approach to treatment is likely going to have the most profound impact in addressing PASC. We are already starting to see some natural compounds (L-Carnitine, Alpha Lipoic Acid, Coenzyme Q10, Curcumin, Vitamin D, Selenium Zinc and probiotics) having an impact of this ill defined syndrome. More properly funded research in the area of nutraceuticals and functional medicine for treatment of PASC is much needed. In the meantime Naturopathic Doctors and Functional Medicine Physicians have many tools to start treating PASC with safe and effective protocols.
References
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It was my hope to find an effective alternative to Cannabidiol (CBD) that wouldn’t land me in jail when I travel; so is PEA the new CBD?
PEA stands for Palmitoylethanolamide. It is a fatty acid that is found in Eggs, Cheese, Meats and Peanuts. We also make PEA during stress, infections, inflammation, trauma, allergies, pain, cardiac disease, kidney disease and obesity. Much like our endocannabinoids, PEA is responsible for maintaining cellular homeostasis.
How does it work?
While PEA does not have a direct effect on Cannabinoid receptor (CB1 and CB2) it does have similar mechanisms of action to our endocannabinoids and cannabidiol (CBD). PEA looks very similar to our body’s own endocannabinoids (AEA and 2-AG). These similarities allow PEA to exert effects similar to our AEA and 2-AG.
PEA down regulates mast cells, which are responsible for the release of histamine and other inflammatory mediators. PEA can therefore be a powerful molecule for immune heath, inflammation, pain, neuro-protection and allergies. PEA has direct action on receptors GPCR55 and GPR119, which produce effects similar to activation of CB1 and CB2 by endocannabinoids, THC and CBD. PEA also acts similarly to CBD by affecting the breakdown of endocannabinoids via inhibition of the enzymes FAAH and MAGL.
The Research
Several studies have shown that when PEA is used with opioid type drugs for low back pain, the dose of the opioids could be reduced significantly. PEA was found to exert pain relief animal models of inflammation and neuropathic pain. These analgesic effects are thought to be due to increasing endocannabinoid levels similarly to how CBD works. All in all many studies have revealed that PEA exerts similar effects to CBD. So I thought I would give this supplement a whirl, as a alternative to CBD (especially for travel) would be an important option for patients using CBD.
My 5-day Trial with PEA
I took the supplement P.E.A. Activate from AOR , which contains 600mg PEA per lozenge. My daily dose was two lozenges per day and I did that for 5 days. I noticed a strange light-headed feeling about 5 minutes after chewing my first lozenge. The feeling lasted for a bout 30min. I was excited that I actually felt a bit different after that fist dose by unfortunately each dose produced a similar effect (a light relaxing feeling) that only lasted between 30-60min. There didn’t seem to be much carry over from one dose to another. The effects were always pretty fast acting but short-lived. Furthermore I had a return of some muscle soreness that was absent for most of the time that I was taking my CBD supplement. So, it seemed like, for me, the PEA was not having the same effect that I had experienced while on CBD.
In summary, the effects that I experienced during my PEA trial were fast acting but short-lived. PEA may therefore be a useful tool for acute episodes of anxiety, pain etc… but it did not have the same accumulative and long term effects that I experienced with CBD. The research on PEA is compelling and it is possible that this supplement warrants a more long-term trial. According to the research PEA seems to be a potential alternative to CBD but from my experience it falls a bit short. Check out my video review of PEA here.
“Let food be thy medicine, and let medicine be thy food”; a famous quote from the Classical Grecian physician Hippocrates. Lions Mane mushrooms are a perfect embodiment of this philosophy; as delicious as it is therapeutic.
Lions mane (Hericium Erinaceus) is a white clumpy mushroom with long dangling spines that tends to grow in late summer/early fall on hardwoods.
I was first introduced to Lion’s Mane a few years ago when I had a few patients tell me they were using an extract of the mushroom to help with memory. Supplements that enhance brain activity, AKA Nootropics, have always tweaked my interest as one of my areas of clinical focus is in neurology. At first I thought that maybe this is the newest “superfood fad” but once I began to investigate the research on this mushroom my opinion quickly changed.
It was clear that Lions Mane had some legitimate therapeutic value in inflammation, the immune system, psychiatric conditions, cognitive enhancement, diabetes, heart disease, bowel disease and cancer.
Inflammation and Depression
A 2012 study demonstrated that Lions Mane mushroom contains several compounds that have moderate to high levels of antioxidant capacity. This translates into an anti-inflammatory effect in the body. A 2015 study demonstrated that participants who consumed Lions Mane had less depressive symptoms and improvements in blo-markers of depression which was attributed to it’s anti-inflammatory effects. Another study demonstrated that Lions Mane can enhance immune function possibly by reducing inflammation and oxidative stress.
Immune
Not only does Lions Mane help boost immune function by reducing oxidative stress, it also seems to benefit intestinal immune function. A study on mice revealed that some of the proteins in the mushroom help encourage the growth of beneficial bacteria in the gut.
Memory
Cognitive enhancement is the main reason that I see people taking this mushroom. It is possible that it does have some cognitive enhancement properties but all the research so far has been done on animals. One such study found that mice given a lion’s mane supplement had better object recognition and recognition memory. Other research suggests that Lions Mane may have the potential to prevent or treat conditions of cognitive decline like Alzheimer’s and Parkinson’s disease.
Heart Health
Research on rats has demonstrated that Lions Mane may have cholesterol lowering effects and blood pressure lowering effects. Compounds in Lions Mane may help in the production of Nitric Oxide, which helps keep blood vessels relaxed.
Cancer
The antioxidant properties of Lions Mane may contribute to some anti-cancer effects seen in rat and in vitro studies. One in vitro study indicated that Lions Mane has activity against human leukemia cells. Another study showed that in mice, Lions Mane has activity against Liver, Colon and Gastric cancer cells.
Diabetes
After 4 weeks of Lions Mane supplementation, rats with diabetes had lower blood sugar levels than those who did not receive the mushroom. Diabetes can often result in life altering nerve damage. A 2015 study showed that diabetic rats given an extract of Lions Mane had reduced nerve pain and improved antioxidant activity after 6 weeks.
Digestive Health
I previously discussed how Lions mane can have anti-inflammatory effect of the digestive tract, as well as benefitting the growth of “good” intestinal bacteria. Another study demonstrated that Lions Mane has some interesting antimicrobial effects. Notably, Lions Mane seems to inhibit the growth of H-pylori, a bacteria responsible for close to 80% of stomach ulcers.
Nerve Repair
One of the most fascinating health benefits of Lions Mane came out of a rat study. Rats with nerve damage who were given daily extracts of Lions mane had quicker nerve cell regeneration than those who did not.
Culinary
Up until a few weeks ago I thought Lions Mane was an exotic mushroom that was only used therapeutically as a supplement. Recently, I found myself in a local Farmers Market and low and behold a mushroom farmer was selling fresh Lions Mane; I was amazed! I asked the farmer “how do I prepare this”? He told me to cut the mushroom in ½ inch slices and in a hot pan with butter, sear both sides. So, I bought some and followed his advice, and discovered that Lions Mane is absolutely delicious! It is now one of my favorite cooking mushrooms and I have since heard from many foodies and chefs that it is one of their favorites too. So let food be thy medicine everyone, and cook up some Lions Mane this fall!
Citations
Leonard, Jayne. “What are the benefits of lion’s mane mushrooms?.” Medical News Today. MediLexicon, Intl., 22 Oct. 2018. Web.
30 Oct. 2019. <https://www.medicalnewstoday.com/articles/323400.php>
Leonard, J. (2018, October 22). “What are the benefits of lion’s mane mushrooms?.” Medical News Today. Retrieved from
https://www.medicalnewstoday.com/articles/323400.php.
| Lion’s Mane Mushroom, <i>Hericium erinaceus</i> (Bull.: Fr.) Pers. Suppresses H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia. |
| Kushairi N, Phan CW, Sabaratnam V, David P, Naidu M. |
| Antioxidants (Basel). 2019 Aug 1;8(8). pii: E261. doi: 10.3390/antiox8080261. |
| PMID: 31374912 [PubMed] Free Article |
| Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats. |
| Lee LY, Li IC, Chen WP, Tsai YT, Chen CC, Tung KC. |
| Int J Med Mushrooms. 2019;21(4):401-411. doi: 10.1615/IntJMedMushrooms.2019030320. |
| PMID: 31002635 [PubMed – indexed for MEDLINE] |
| In Vitro and In Vivo Inhibition of Helicobacter pylori by Ethanolic Extracts of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes). |
| Wang G, Zhang X, Maier SE, Zhang L, Maier RJ. |
| Int J Med Mushrooms. 2019;21(1):1-11. doi: 10.1615/IntJMedMushrooms.2018029487. |
| PMID: 30806251 [PubMed – indexed for MEDLINE] |
| Dietary Supplementation of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice. |
| Rossi P, Cesaroni V, Brandalise F, Occhinegro A, Ratto D, Perrucci F, Lanaia V, Girometta C, Orrù G, Savino E. |
| Int J Med Mushrooms. 2018;20(5):485-494. doi: 10.1615/IntJMedMushrooms.2018026241. |
| PMID: 29953363 [PubMed – indexed for MEDLINE] |
| A Polysaccharide Isolated from Mycelia of the Lion’s Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells. |
| Wang M, Zhang Y, Xiao X, Xu D, Gao Y, Gao Q. |
| Int J Med Mushrooms. 2017;19(12):1053-1060. doi: 10.1615/IntJMedMushrooms.2017024975. |
| PMID: 29431066 [PubMed – indexed for MEDLINE] |
| Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis. |
| Qin M, Geng Y, Lu Z, Xu H, Shi JS, Xu X, Xu ZH. |
| Int J Med Mushrooms. 2016;18(3):227-34. doi: 10.1615/IntJMedMushrooms.v18.i3.50. |
| PMID: 27481156 [PubMed – indexed for MEDLINE] |
Cold and Flu season is here! Now that kids are back to school and the season is changing we should start thinking about preventing colds and flu. As a Naturopathic Doctor part of my job is counseling parents on safe and effective ways to treat and prevent colds and flu for the whole family. Here are 5 things that will help prevent colds and flu and can even help to ameliorate symptoms and shorten duration of an active infection.
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Probiotics
Probiotics help boost the immune system – Studies have shown that probiotics affect immune cells throughout the body. When certain strains of probiotics are introduced into our intestine they help to repair intestinal cells and they boost production of antimicrobial substances. In one study, 326 children aged 3-5 years were randomly assigned to receive, in double-blind fashion, probiotic supplementation. Treatments were given twice per day in divided doses for 6 months, including the winter season. Compared with placebo, the probiotic group had the following results; fever reduction 53-73%, cough reduction 41-62%, decreased runny nose 28-59%, decreased need for antibiotics 68-82%, reduced absence from school 28-32%.
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Elderberry
Elderberry extracts inhibit bacteria and viruses – Not only does elderberry syrup taste great, studies have shown that it inhibits the bacteria and viruses associated with common colds and the flu. One study demonstrated that an elderberry liquid extract possesses antimicrobial activity against both streptococci bacteria and influenza viruses. Another study looked at 312 air travellers flying from Australia to an overseas destination. Those travellers who took an elderberry extract before, during and after travel had fewer colds, less sick days and less symptoms.
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Vitamin C
Vitamin C supports immune cells – Vitamin C is very important for optimal immune system functioning. Vitamin C helps immune cells get to where they need to be, kill pathogens effectively, protect the body from damage and clean up after battling infections. Studies have shown that adequate vitamin C in the blood helps prevent infections, is necessary to fight infections and helps with recovery. The recommended daily intake of vitamin C is 100-200mg/day; however during active infection, the metabolic demand increases and therefore the requirement for vitamin C is likely to be higher. Even in this day and age, vitamin C is the fourth leading nutrient deficiency in North America. Poor diet and increases in free radical exposure due to an unhealthy lifestyle may be contributing factors. Excellent sources of vitamin C are Broccoli, Citrus Fruits and Berries.
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Zinc
Zinc is essential for immune system communication – The importance of zinc for proper immune function has been well established. Zinc deficiency undoubtedly causes immune system malfunction. The cells of our body are in constant communication. During infection there is a need for effective communication between immune cells in order to get rid of the “bad guys”. Communication happens in the form of chemical messengers and enzymes. Zinc is an essential component of these chemicals and enzymes. As with vitamin C, during active infection our requirement for zinc is likely to increase. Studies have shown that Zinc supplementation during infection can shorten the duration of the illness. Excellent dietary sources of zinc include: Meat, Shellfish, Legumes, Nuts and Seeds. Supplementation may be important with a vegan or vegetarian diet.
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Vitamin D
Vitamin D is the supervisor of the immune system –Vitamin D has many functions in the body, and receptors for vitamin D can be found on many different tissues. One important function for vitamin D is in the modulation of our immune system. Studies have suggested that vitamin D is able to both calm down and rev-up the immune system according to what our body needs it to do. This is why Vitamin D is thought to be as important in autoimmune disorders as it is in infections.
Vitamin D deficiency can cause the immune system to behave erratically. Unfortunately in Canada we have one of the highest incidences of vitamin D deficiency in the world. Our primary source of vitamin D is from sunlight and therefore supplementation becomes important especially during the winter months. Studies have shown that there is a higher incidence of upper respiratory tract infections in athletes who are deficient in the vitamin and who train in the wintertime. Supplementation had preventative and symptom reducing effects. Aside from sunlight, some dietary sources of vitamin D are: fortified foods, fatty fish, beef liver, egg yolks and cheese.
Even vitamins and minerals at high dosages can be dangerous, especially in children. It is always recommended to consult with a health care professional, such as a Naturopathic Doctor, before supplementing on your own.
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Leyer, GJ et al. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics 2009; 124-179. Walker, WA. Mechanisms of action of probiotics. Clin Infect Dis. 2008; 46 (Suppl2): S87-91.
Curr Opin Gastroenterol. 2011 October ; 27(6): 496–501. doi:10.1097/MOG.0b013e32834baa4d. Probiotics and immune health Fang Yana and D.B. Polkb,c,d
Elderberry Supplementation Reduces Cold Duration
and Symptoms in Air-Travellers: A Randomized,
Double-Blind Placebo-Controlled Clinical Trial Evelin Tiralongo 1,2, *, Shirley S. Wee 2,3 and Rodney A. Lea 4 Received: 8 February 2016; Accepted: 18 March 2016; Published: 24 March 2016
Krawitz et al. BMC Complementary and Alternative Medicine 2011, 11:16
http://www.biomedcentral.com/1472-6882/11/16
Inhibitory activity of a standardized elderberry
liquid extract against clinically-relevant human
respiratory bacterial pathogens and influenza A
and B viruses Christian Krawitz1†, Mobarak Abu Mraheil1†, Michael Stein2, Can Imirzalioglu1, Eugen Domann1, Stephan Pleschka2*,
Torsten Hain1*
Vitamin C and Immune Function Anitra C. Carr 1, * and Silvia Maggini 2
1 Department of Pathology, University of Otago, Christchurch, P.O. Box 4345, Christchurch 8140, New Zealand
2 Bayer Consumer Care Ltd., Peter-Merian-Strasse 84, 4002 Basel, Switzerland; silvia.maggini@bayer.com* Correspondence: anitra.carr@otago.ac.nz; Tel.: +643-364-0649 Received: 21 September 2017; Accepted: 31 October 2017; Published: 3 November 2017
Biofactors. 2014 Jan-Feb;40(1):27-40. doi: 10.1002/biof.1114. Epub 2013 Jun 27.Zinc signals and immune function. Haase H1, Rink L.
Cochrane Database Syst Rev. 2013 Jun 18;(6):CD001364. doi: 10.1002/14651858.CD001364.pub4. Zinc for the common cold.
Vitamin D3 Supplementation Reduces the Symptoms
of Upper Respiratory Tract Infection during Winter
Training in Vitamin D-Insufficient Taekwondo
Athletes: A Randomized Controlled Trial Hyun Chul Jung 1 , Myong-Won Seo 2 , Sukho Lee 3 , Sung Woo Kim 2 and Jong Kook Song 2, * 1 Department of Kinesiology, College of Health Sciences, University of Louisiana at Monroe, 700 University
Avenue, Monroe, LA 71209, USA; jung@ulm.edu
2 Department of Taekwondo, College of Physical Education, Kyung Hee University, 1732 Deokyoungdaero, Giheung-gu, Yongin-si, Gyeonggi-do 17014, Korea; smilly1004@khu.ac.kr (M.-W.S.); kswrha@khu.ac.kr (S.W.K.)
3 Department of Counseling, Health, and Kinesiology, College of Education and Human Development,Texas A&M University-San Antonio, One University Way, San Antonio, TX 78224, USA; slee@tamusa.edu* Correspondence: jksong@khu.ac.kr; Tel.: +82-31-201-2708 Received: 2 August 2018; Accepted: 10 September 2018; Published: 14 September 2018
Mechanisms Underlying the Regulation of Innate and
Adaptive Immunity by Vitamin D Ran Wei and Sylvia Christakos *
Received: 25 June 2015 ; Accepted: 15 September 2015 ; Published: 24 September 2015 Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers, the State University of New Jersey, 185 South Orange Ave, Newark, NJ 07103, USA; weira@njms.rutgers.edu
* Correspondence: christak@njms.rutgers.edu; Tel.: +973-972-4033; Fax: +973-972-5594
Patient focused integrative health care. Utilizing effective natural approaches designed to be used alone or to compliment conventional medical care.
